ID A0A1U7XW44_NICSY Unreviewed; 854 AA.
AC A0A1U7XW44;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=General negative regulator of transcription subunit 3 isoform X3 {ECO:0000313|RefSeq:XP_009791159.1};
GN Name=LOC104238492 {ECO:0000313|RefSeq:XP_009791159.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009791159.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009791159.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009791159.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CNOT2/3/5 family.
CC {ECO:0000256|ARBA:ARBA00007682}.
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DR RefSeq; XP_009791159.1; XM_009792857.1.
DR AlphaFoldDB; A0A1U7XW44; -.
DR SMR; A0A1U7XW44; -.
DR GeneID; 104238492; -.
DR OrthoDB; 10289at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0030015; C:CCR4-NOT core complex; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 2.30.30.1020; CCR4-NOT complex subunit 2/3/5, C-terminal domain; 1.
DR InterPro; IPR038635; CCR4-NOT_su2/3/5_C_sf.
DR InterPro; IPR012270; CCR4-NOT_su3/5.
DR InterPro; IPR040168; Not2/3/5.
DR InterPro; IPR007282; NOT2/3/5_C.
DR InterPro; IPR007207; Not_N.
DR PANTHER; PTHR23326; CCR4 NOT-RELATED; 1.
DR PANTHER; PTHR23326:SF1; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3; 1.
DR Pfam; PF04153; NOT2_3_5_C; 1.
DR Pfam; PF04065; Not3; 1.
DR PIRSF; PIRSF005290; NOT_su_3_5; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 4..236
FT /note="CCR4-Not complex component Not N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04065"
FT DOMAIN 711..848
FT /note="NOT2/NOT3/NOT5 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04153"
FT REGION 109..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 132..159
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 291..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 854 AA; 93291 MW; 3367E7B0E3EA6FED CRC64;
MGASRKLQGE IDRVLKKVQE GVDVFDSIWN KVYDTDNANQ KEKFEADLKK EIKKLQRYRD
QIKTWIQSSE IKDKKVSASY EQALMDARKL IEREMERFKI CEKETKTKAF SKEGLGQQPK
TDPREKAKSE TRDWLNNVVG ELENQIDTFE AELEGLSVKK GKQRPPRLVH LETSIVRHKA
HIMKLELILR LLDNDELSPE QVNDVKDFLD DYVERNQEDF DEFSDVDELY STLPLDKVES
LEDLVTVGPP GLVKGVTVAS AVLSVKNSLA SSPAQSSVSV TSSAQQAACV QDQADETASQ
DSSSEAVART PPPKSSAVAA SAPTTPAGSH ATQGAVAALS PTSMSNAIKE DDVTSFPGRK
PSPALNETAL RGVNRGSLSN QPVASITLGS GGAATGNGGL GAIPSASEVT KRNTLGSEDR
LGSNAMGQAL VSPLANRMMM SQAAKATDGI GVADGANPGD ATVMTGRVFS PSVGPGMQWR
PGSSFQNQNE AGQFRGRTEI APDQREKFLQ RFQQVQQQGQ SNLLGIPPLS GGNLKQFSSQ
QQNPLLPQFN SQSSSVSPQL GLGVGVQASS INSVASSASL QQQPDAGHSK VEDLQQQQTL
PEDSSTDSAA NPGPGKNLLN EDDMKASYGL DTPMQGGVNG SIAEPSPRPR DIDLSPGQPL
QSSQPSGSLG VIGRRSVADL GAIGDNLSAS TANSGGMHDQ LYNLQMLESA FYKLPQPKDS
ERAKSYTPRH PAVTPPSYPQ VQAPIVNNPA FWERLGADNY GTDTLFFAFY YQQNTYQQYL
AAKELKKQSW RYHRKYNTWF QRHEEPTVAT DDFEQGTYVY FDFHIANDEQ HGWCQRIKQE
FTFEYNYLED ELIV
//
