ID A0A1U7Y4H0_NICSY Unreviewed; 613 AA.
AC A0A1U7Y4H0;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Probable acyl-activating enzyme 1, peroxisomal {ECO:0000313|RefSeq:XP_009798028.1};
GN Name=LOC104244318 {ECO:0000313|RefSeq:XP_009798028.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009798028.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009798028.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009798028.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene
CC biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step
CC 1/2. {ECO:0000256|ARBA:ARBA00004930}.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR RefSeq; XP_009798028.1; XM_009799726.1.
DR AlphaFoldDB; A0A1U7Y4H0; -.
DR STRING; 4096.A0A1U7Y4H0; -.
DR GeneID; 104244318; -.
DR KEGG; nsy:104244318; -.
DR eggNOG; KOG1176; Eukaryota.
DR OrthoDB; 2596785at2759; -.
DR UniPathway; UPA00372; UER00547.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0016207; F:4-coumarate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0009698; P:phenylpropanoid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd12118; ttLC_FACS_AEE21_like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43859; ACYL-ACTIVATING ENZYME; 1.
DR PANTHER; PTHR43859:SF65; ACYL-ACTIVATING ENZYME 1, PEROXISOMAL-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Phenylpropanoid metabolism {ECO:0000256|ARBA:ARBA00023051};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701}.
FT DOMAIN 90..472
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 522..596
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 613 AA; 68046 MW; 7FB87008C3E14DAC CRC64;
MSLSSTINMS HFFKDSRLGG WFFNGSNQAH FSCTTTSGVA KFFPKTLKMS KRLCQLSGDH
DRQVSEPWAS VEGMIKCDAN YVPLTPISFL ERAANVFSDR TSVIYGSSVT YTWEETYARC
IKLASALVQL GISRGDVVAT LAPNVPAMQE LHFAVPMAGA ILCTLNTRLD SAMISTLLIH
SEAKVIFVDQ QLLQLAQGAI SLLAIKKTQP PLLVVISEKS KNIDNSNTYE YESLLKSGHS
DFSIRWPISE FDPISINYTS GTTSGPKGVV YSHRGAYLNS IATFLLHEMS SLPIYLWTVP
TFHCNGWCLI WGLAAFGGTN VCLRHVSAKE IFESISLYKV TYMGGAPTVL NMIVNSSPRD
RKPLPHKVKI MTGGSPPPPQ ILSRMEELGF GVNHLYGLTE TYGPGIYCLW KPEWDSLPPD
ERFTLKARQG VQHLCLEEVD VRDSATMEKV PADGVTMGEV MFRANTVMSG YWKDVKATEE
AFRGGRFHSG DLAVKHPDGY IDIKDRLKDI IISGGENIST VEVERALYRH PAVFEAAVVA
RPDNHWGQTP CAFVKLKEGF DVSDKEIINF CRDNLPHYMA PRTVIFQDLP KTTTGKIQKF
ILKEKAKALG SLF
//
