ID A0A1U7Y5V8_NICSY Unreviewed; 1437 AA.
AC A0A1U7Y5V8;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Pleiotropic drug resistance protein 1 {ECO:0000313|RefSeq:XP_009799502.1};
GN Name=LOC104245578 {ECO:0000313|RefSeq:XP_009799502.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009799502.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009799502.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009799502.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000256|ARBA:ARBA00006012}.
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DR RefSeq; XP_009799502.1; XM_009801200.1.
DR GeneID; 104245578; -.
DR KEGG; nsy:104245578; -.
DR eggNOG; KOG0065; Eukaryota.
DR OrthoDB; 1384804at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013581; PDR_assoc.
DR PANTHER; PTHR48040:SF27; PLEIOTROPIC DRUG RESISTANCE PROTEIN 1; 1.
DR PANTHER; PTHR48040; PLEIOTROPIC DRUG RESISTANCE PROTEIN 1-LIKE ISOFORM X1; 1.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF08370; PDR_assoc; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 534..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 567..586
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 652..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 677..700
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 707..726
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 760..787
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1182..1203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1259..1286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1298..1322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1328..1347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1359..1379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1406..1429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 165..438
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 839..1091
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 796..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..820
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1437 AA; 161969 MW; 9FA7ED36EE3F0219 CRC64;
MEPADLSNLR GRSLRASIRG SMRGSIRENS NSIWRNNGAE VFSRSARDED DEEALKWAAL
EKLPTYDRLR KGILFGSQGA AAEVDVDDLG VLERKNLLER LVKVADEDNE KFLLKLKNRI
DRVGIDFPSI EVRFEHLNID ADAYVGSRAL PTFTNFISNF VEGLLDSIHI LPSRKRQVTI
LKDVSGIVKP CRMTLLLGPP GSGKTTLLLA LAGKLDSALK VTGKVTYNGH ELHEFVPQRT
AAYISQHDLH IGEMTVRETL EFSARCQGVG SRYEMLAELS RREKAANIKP DADIDMFMKA
ASTEGQEAKV VTDYILKILG LDICADTMVG DQMIRGISGG QKKRVTTGEM IVGPSKALFM
DEISTGLDSS TTYSIVNSLK QSVRIMKGTA LISLLQPAPE TYNLFDDIIL LSDGYIVYQG
PREDVLNFFE SMGFKCPERK GAADFLQEVT SKKDQQQYWV RRDEPYRFIT SKEFAEAYQS
FHVGRKVSDE LATTFDKSKS HPAALTTQKY GIGKKQLLKV CTERELLLMQ RNSFVYLFKF
FQLLVIALMT MTIFFRTKMP RDSAEDGSIY SGALFFVVIM IMFNGLSELP MTLYKLPVFY
KQRDFLFYPS WAYAIPSWIL KIPVTFAEVG MWVFLTYYVI GFDPNVGRFF KQFLLLLLVN
QMASALFRFI AAVGRTMGVA STFGAFALLL QFALGGFMLA RNDVKDWWIW GYWTSPLMYS
VNAILVNEFD GQKWKHIVAG GTEPLGAAVV RARGFFPDAY WYWIGVGALA GFTVMFNIAY
SVALAYLNPF DKPQATISDE SENNENTESS PQITSTQEGD SVSENKKKGM VLPFDPHSIT
FDEVVYSVDM PPEMSESGTS DNRLVLLKSV SGAFRPGVLT ALMGVSGAGK TTLMDVLAGR
KTGGYIDGSI KISGYPKKQE TFARISGYCE QNDIHSPYVT VFESLVYSAW LRLPQDIDEQ
KRMMFVDEVM DLVELTPLRS ALVGLPGVNG LSTEQRKRLT IAVELVANPS IIFMDEPTSG
LDARAAAIVM RAVRNTVDTG RTVVCTIHQP SIDIFEAFDE LFLMKRGGQE IYVGPLGRQS
CHLIKYFESI PGVSKIVEGY NPATWMLEVT ASSQEMALGV DFTELYKKSD LYRRNKALID
ELSVPRPGTS DLHFDSEFSQ PFWTQCMACL WKQHWSYWRN PAYTAVRFIF TTFIALIFGT
MFWDIGTKVS RNQDLVNAMG SMYAAVLFLG VQNSSSVQPV VSVERTVFYR EKAAGMYSAI
PYAFAQVLIE IPYIFVQATV YGLIVYSMIG FEWTVAKFFW YFFFMFFTFL YFTYFGMMTV
AVTPNQNVAS IVAGFFYTVW NLFSGFIVPR PRIPIWWRWY YWGCPIAWTL YGLVASQFGD
LQDPLIDQNQ TVEQFLRSNL GFKHDFLGVV AAVIVAFAVV FAFTFALGIK AFNFQRR
//
