ID A0A1U7Y7U7_NICSY Unreviewed; 950 AA.
AC A0A1U7Y7U7;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Respiratory burst oxidase homolog protein E-like isoform X1 {ECO:0000313|RefSeq:XP_009799187.1, ECO:0000313|RefSeq:XP_009799188.1};
GN Name=LOC104245292 {ECO:0000313|RefSeq:XP_009799187.1,
GN ECO:0000313|RefSeq:XP_009799188.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009799188.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009799187.1, ECO:0000313|RefSeq:XP_009799188.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009799187.1,
RC ECO:0000313|RefSeq:XP_009799188.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the RBOH (TC 5.B.1.3) family.
CC {ECO:0000256|ARBA:ARBA00007975}.
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DR RefSeq; XP_009799187.1; XM_009800885.1.
DR RefSeq; XP_009799188.1; XM_009800886.1.
DR STRING; 4096.A0A1U7Y7U7; -.
DR GeneID; 104245292; -.
DR KEGG; nsy:104245292; -.
DR eggNOG; KOG0039; Eukaryota.
DR OrthoDB; 367877at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0050664; F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor; IEA:InterPro.
DR GO; GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.
DR CDD; cd00051; EFh; 1.
DR CDD; cd06186; NOX_Duox_like_FAD_NADP; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR000778; Cyt_b245_heavy_chain.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR013112; FAD-bd_8.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR InterPro; IPR013121; Fe_red_NAD-bd_6.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR013623; NADPH_Ox.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR11972; NADPH OXIDASE; 1.
DR PANTHER; PTHR11972:SF44; RESPIRATORY BURST OXIDASE HOMOLOG PROTEIN E; 1.
DR Pfam; PF08022; FAD_binding_8; 1.
DR Pfam; PF01794; Ferric_reduct; 1.
DR Pfam; PF08030; NAD_binding_6; 1.
DR Pfam; PF08414; NADPH_Ox; 1.
DR PRINTS; PR00466; GP91PHOX.
DR SFLD; SFLDG01168; Ferric_reductase_subgroup_(FRE; 1.
DR SFLD; SFLDG01169; NADPH_oxidase_subgroup_(NOX); 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS51384; FAD_FR; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxidase {ECO:0000256|ARBA:ARBA00022559};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 392..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 475..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..595
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 267..302
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 625..746
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 950 AA; 107469 MW; AE46A6E8CA0C29CF CRC64;
MQLKQFLRSS SFGSCSSKRS TYSRNFDLPE DTPATEIFET GPEYVGGAML PIFLNDLRQN
SDLQDLVEVT LELDDNSIVL CSVAPTPSHN AEGNGSEEEA PNGFLARSAS AASKLRRKFS
WIRSPSVRSR TSAAPSEDDH FQFYNHNSNH NNTTNTLSAR EEMKSKLKLV RSKSTAQRAL
GGLRFISKTT GESDTNVQWK KVEARFDALA KDGLLAREDF GDCIGMTDSK EFAVGVFDAL
VRRRRQKTAK ITKAELHEFW LQISDQSFDA RLQIFFDMAD RNGDGKITRD EVQELIMLSA
SANKLSKLKE RAAEYASLIM EELDPDDLGY IELWQLETLL LQRDNYMNYS RPLSTTSVGW
SQNLGTRSKT RNLVKRASYG LKCLVLDNWQ RAWILLLWVM IMAGLFTWKF LQYRRRAAFQ
VMGYCLATAK GAAETLKLNM ALVLLPVCRN ILTWLRSTRA KLLVPFDDNI NFHKIIAYAI
AVGILLHAGN HLACDFPRLI NSSPEKFALI ASDFDNVKPT FKSLLTGIEG VTGIAMVILM
AIVFTLATRG FRRNVLKLPP PFNRLTGFNA FWYSHHLLAV VYVLLIVHGT FLFLVHQWWQ
KTTWMYISMP LLLYVAERSL RTCRSEHYTA KILKVSVLPG DVFSLTLSKP NGFKYKSGQY
IFLQCPTISS FEWHPFSITS APGDDYLSVH IRIVGDWTNE LKRVFTEDDS SACEIGRAKF
EERGNVDQRG LPRLLVDGPY GAAAQDYQNY DVLLLVGLGI GATPFISILK DLLNNSRSEE
QLDSNTETSA SDDSWTSYAS SSAASSGKKK SIRTKSAHFY WVTREPGSFE WFKGVMNEVA
EMDHKGLIEM HNYLTSVYEE GDARSTLITM VQALNHAKHG VDILSGTQVR THFARPKWKE
VFSKIASKHP YSTVGVFYCG LPALAKELRK LSQELTYKTS TRFEFHKEYF
//
