ID A0A1U7YH82_NICSY Unreviewed; 962 AA.
AC A0A1U7YH82;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LOC104244460 {ECO:0000313|RefSeq:XP_009798185.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009798185.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009798185.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009798185.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_009798185.1; XM_009799883.1.
DR AlphaFoldDB; A0A1U7YH82; -.
DR GeneID; 104244460; -.
DR OrthoDB; 991910at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14066; STKc_IRAK; 1.
DR Gene3D; 2.60.120.430; Galactose-binding lectin; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR021720; Malectin_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR48006; LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED; 1.
DR PANTHER; PTHR48006:SF72; LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE RFK1-RELATED; 1.
DR Pfam; PF00560; LRR_1; 3.
DR Pfam; PF11721; Malectin; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|RefSeq:XP_009798185.1};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000313|RefSeq:XP_009798185.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000313|RefSeq:XP_009798185.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..962
FT /note="non-specific serine/threonine protein kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010524690"
FT DOMAIN 619..892
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 939..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 962 AA; 107128 MW; F4C64903AE4B6E08 CRC64;
MLTAKRGVLS WILVVNYFLL LNLGESRVAQ EEVDILEQIA VTMGATHWKF NGELCQIEAV
MVTTDRPNWS ETDVKCNCSI GNDTLCHVVA ITLKGISLPG VLPPELVKLP YIQQVDFAYN
YLSGSIPAEW ASTPLSFISV LVNRLSGEIP KELGNITSLT YINLEGNQFS GIIPSELGKL
INLKTLILSS NQLEGELPTS LSGLVNLTDF RISDNNVSGP IPDFIQNWKQ LAKLELHASG
LEGPIPSGIS LLNMLTDLRI SDINGPMQEF PPLNNMTGLV ILVLRNCNLS GVIPGYIWQL
KTIQTFDVSF NKLVGTIPDD ISARTMLKFV FLSGNMLSGN VPDSILKNGI NVDLSYNNFT
WQGPDQPACR QNTNYYINLY KSSSAVSILR NVLPCTEDLT CPRYGCSLHV NCGGNDFTVK
ENNRQLDYEG DAQVEGGSAR YFRSNKYWGF SSTGDFMDDA NDQNTRFIES TQSLSELYSG
ARASPLSLTY FRYCLENGNY SVSLHFAEIM FKDDRTYYNL GRRVFDIYIQ EKLVWKDFNI
EEEARGVKRP VIRRFNATVT DSVLEIRLYW GGKGTTRIPL RGHYGALISA ISVDSNLNGV
ELQMVCFTLK QIKAATKNFD ASNKIGEGGF GPVYKGQLPD GTLVAVKQLS SQSKQGNREF
LNEISTISCL QHPNLVKLHG CCIEADQLLL VYEYLDNNSL AGALFEDSRL TLDWPTRFRI
CLGIAKGLAF LHEESSLKIV HRDIKATNVL LDGQLNPKIS DFGLARLNEE EKTHISTRVA
GTIGYMAPEY ALWGYLTDKA DVYSFGVVLL ETVSGKNNNN YMPSNHSICL LDWACHLQQS
GSIEELIDQR LGSDINKQEV ERIVKVALLC TSATPSLRPI MSEVVSMFEG RLAIPDEIPE
ANTYSNDLRF KAMKDFHQER QKQKLTGSQT QNTMTIQTDM GSSSASTTNL FDSVQFQDQT
DT
//
