ID A0A1U7YJD0_NICSY Unreviewed; 1643 AA.
AC A0A1U7YJD0;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Transcription elongation factor spt6 {ECO:0000256|PIRNR:PIRNR036947};
GN Name=LOC104249461 {ECO:0000313|RefSeq:XP_009804197.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009804197.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009804197.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009804197.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transcription elongation factor that enhances transcription
CC elongation by RNA polymerase II (RNAPII).
CC {ECO:0000256|PIRNR:PIRNR036947}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR036947}.
CC -!- SIMILARITY: Belongs to the SPT6 family. {ECO:0000256|ARBA:ARBA00009253,
CC ECO:0000256|PIRNR:PIRNR036947}.
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DR RefSeq; XP_009804197.1; XM_009805895.1.
DR STRING; 4096.A0A1U7YJD0; -.
DR GeneID; 104249461; -.
DR KEGG; nsy:104249461; -.
DR eggNOG; KOG1856; Eukaryota.
DR OrthoDB; 170310at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0032968; P:positive regulation of transcription elongation by RNA polymerase II; IEA:UniProtKB-UniRule.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd09928; SH2_Cterm_SPT6_like; 1.
DR CDD; cd09918; SH2_Nterm_SPT6_like; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 1.10.10.650; RuvA domain 2-like; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 1.10.10.2740; Spt6, Death-like domain; 1.
DR Gene3D; 1.10.150.850; Spt6, helix-hairpin-helix domain; 1.
DR Gene3D; 1.10.3500.10; Tex N-terminal region-like; 1.
DR Gene3D; 3.30.420.140; YqgF/RNase H-like domain; 1.
DR InterPro; IPR041692; HHH_9.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR049540; Spt6-like_S1.
DR InterPro; IPR028083; Spt6_acidic_N_dom.
DR InterPro; IPR042066; Spt6_death-like.
DR InterPro; IPR032706; Spt6_HHH.
DR InterPro; IPR035420; Spt6_SH2.
DR InterPro; IPR035018; Spt6_SH2_C.
DR InterPro; IPR035019; Spt6_SH2_N.
DR InterPro; IPR028231; Spt6_YqgF.
DR InterPro; IPR023323; Tex-like_dom_sf.
DR InterPro; IPR023319; Tex-like_HTH_dom_sf.
DR InterPro; IPR017072; TF_Spt6.
DR InterPro; IPR006641; YqgF/RNaseH-like_dom.
DR InterPro; IPR037027; YqgF/RNaseH-like_dom_sf.
DR PANTHER; PTHR10145; TRANSCRIPTION ELONGATION FACTOR SPT6; 1.
DR PANTHER; PTHR10145:SF6; TRANSCRIPTION ELONGATION FACTOR SPT6; 1.
DR Pfam; PF14635; HHH_7; 1.
DR Pfam; PF17674; HHH_9; 1.
DR Pfam; PF14633; SH2_2; 1.
DR Pfam; PF14632; SPT6_acidic; 1.
DR Pfam; PF21710; Spt6_S1; 1.
DR Pfam; PF14639; YqgF; 1.
DR PIRSF; PIRSF036947; Spt6; 1.
DR SMART; SM00316; S1; 1.
DR SMART; SM00732; YqgFc; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158832; Tex N-terminal region-like; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Elongation factor {ECO:0000313|RefSeq:XP_009804197.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036947};
KW Protein biosynthesis {ECO:0000313|RefSeq:XP_009804197.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR036947};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR036947}.
FT DOMAIN 1143..1214
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REGION 1..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1468..1643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..74
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..204
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1494..1513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1547..1561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1643 AA; 186539 MW; 2ACF91A4849B94BF CRC64;
MAGKNVISDD EDEVGIEEEE RDEEPVDGDA VDERDEEDED EEEDEEGQDE YEKDGFIVDD
VEEEEEEDEE DRADSDDERQ KKKKRKKRES ERNYMLDEDD YELLQESNIA VPRPKLESKK
FKRLKKAQRD MDDARSGFSE EEEFDETGRR GRTAEEKLEH SLFGDDEGQP LEDIAEEEER
LEEEEDADIG EEDEMADFIV DEEEVDEHGA PIRRKKVNKK KSRQASGVSS SALQEAHDIF
GDVDELLLRR KQDRAKSGKH DESGEWSERR LEDEFDPTIL AEKYMTEKDE HIRKIDVPER
MQLSEESTGP VPPEAISVEE SNWIYNQLAA GVVPFFKIKK KDSGKSDEES ELPIDKDDIM
RFLDLMHGQK LDVPFIAMYR KEECMSLLKD PEEDETSDDG PNNSDKKPAV RRQKVLWAIQ
DLDRKWLLLQ KRKSALELYY KKRFQEESRR VYDETRLKLN QQLFESITKS LQAADCEREV
DDVDSKFNLH FPPGEVGVDE GQYKRPKRKS QYSICSKAGL WEVASKLGYS AEQFGSHMSC
ESMGDLLEDA RETPEEMASN FTCAMFETPQ AVLKGARHMA AVEISCEPSV RKQVRKTFMD
DAKVSTSPTP DGNVVIDSFH QFAGVKWLRD KPLSDFEDAQ WLLIQKAEEE KLLKVTIKLP
EVVLDKLITD SRDHYLSDGV SKSAQLWNEQ RKLILEDAFF NFLLPSMEKE ARSLLTSRAK
SWLLLEYGKF LWNKVSVGPY QRRESDVGSD EELAPRVMAC CWGPGKPATT FVMLDSSGEV
LDILYAGSLS LRGQNVNDEQ RKKNDQQRLL KFMMDHQPHV VVLGAVNLSC TRLKEDIYEI
IFKMVEDNPR DVGHEMDNLN IIYGDETLPH LYENSRISVD QLPGQSGIVR RAVALGRYLQ
NPLAMVATLC GPGREILSWK LSTLDSFLTP DEKYGMVEQV MVDVTNQVGV DLNLAISHEW
LFAPLQFISG LGPRKAASLQ RSLVRQQTIF TRKDILTEHH LGKKVFVNAV GFLRVRRSGY
TANSNTYIDL LDDTRIHPES YGLAQELAKD IYLNDIGEEN NDDDELLEMA IEHVREKPHL
ARLLKVPNYA KAKDRQDKEE TLNDIRLELM QGFQDWRRQY VEPSQDEEFY MISGESEETL
SEGRIVQATV RRVQPQKAIC ALESGLTGIL TKEDSSDDWR EVNDLTEKMR EGDILTCRIK
SIQKNRYQVF LSCKENDMRN NRYQNNQNLD PYYHEDRSSL QAEKDKVRKE KELAKKHFKP
RMIVHPRFKN ITADESMEFL SDKEPGESIV RPSSRGPSYL TLTLKVYDGV YAHKDIVEGG
KEHKDITSLL RIGKTLKIGE DTFEDLDEVM DRYVDPLVAH LKAMLNYRKF RKGSKAEVDE
LLRIEKSEYP MRIVYSFGIS HEHPGTFILT YIRSSNPHHE YVGLYPKGFK FRKRMFEDID
RLVAYFQRHI DDPHDSAPSI RSVAAMVPMR SPAGGGSGFG GSWGGSSNDS GRRGGQSGDR
DSRPGRNDYR NRSSQDDPSG LPPRPYGGGG RGRGRGRGRG TYGRGRGNND NDGQDSDYGT
QKWGSKEGGG GWGAEVQNSP ARDTFSGGWS GGGSGAGGGS GDGGGWGGNG GGAGWGQDTG
GQSDDSGWGG GKKGSQSGGS GGW
//
