ID A0A1U7YMG7_NICSY Unreviewed; 764 AA.
AC A0A1U7YMG7;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Subtilisin-like protease {ECO:0000313|RefSeq:XP_009800439.1};
GN Name=LOC104246328 {ECO:0000313|RefSeq:XP_009800439.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009800439.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009800439.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009800439.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR RefSeq; XP_009800439.1; XM_009802137.1.
DR AlphaFoldDB; A0A1U7YMG7; -.
DR GeneID; 104246328; -.
DR KEGG; nsy:104246328; -.
DR eggNOG; ENOG502QT5U; Eukaryota.
DR OrthoDB; 11910at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02120; PA_subtilisin_like; 1.
DR CDD; cd04852; Peptidases_S8_3; 1.
DR Gene3D; 2.60.40.2310; -; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034197; Peptidases_S8_3.
DR InterPro; IPR010259; S8pro/Inhibitor_I9.
DR InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR InterPro; IPR045051; SBT.
DR InterPro; IPR041469; Subtilisin-like_FN3.
DR PANTHER; PTHR10795; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN; 1.
DR PANTHER; PTHR10795:SF614; SUBTILISIN-LIKE PROTEASE SBT1.9; 1.
DR Pfam; PF17766; fn3_6; 1.
DR Pfam; PF05922; Inhibitor_I9; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..764
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010559603"
FT DOMAIN 29..117
FT /note="Inhibitor I9"
FT /evidence="ECO:0000259|Pfam:PF05922"
FT DOMAIN 141..576
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 651..755
FT /note="Subtilisin-like protease fibronectin type-III"
FT /evidence="ECO:0000259|Pfam:PF17766"
FT ACT_SITE 150
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 221
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 538
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 764 AA; 82666 MW; 1A9F4173D85967D0 CRC64;
MANCITLYFL FLTILLLTLN PLTMAQSETY IIHMDLSAMP KAFSSHQNWY LTTLASVSDS
SNLGTASNRN SFSSTKLVYA YTNAIHGFSA SLSPSELEVV KNSPGYLSST KDMTVKIDTT
HTSQFLGLNS NSGAWPKSDY GKDVIVGLVD TGIWPESKSY NDNGMTEVPS RWKGECESGT
QFNSSLCNKK LIGARYFNKG LIANNPNITI SMNSARDTDG HGTHTSSTAV GSHVESVSYF
GYAPGAATGM APKAHVAMYK ALWEEGTVLS DILAAIDQAI EDGVDIISLS LGIDGRALYD
DPVAIATFAA MEKGIFVSTS AGNEGLDDQA LHNGTPWVLT VAAGTVDREF IGTLTLGNGV
SVTGLSLYPG NFSSSESSIV FLKTCLEEKE LEKNAHKIAV CYDTNGSISD QVYNVKNTKV
AGGIFITNYT DLEFYLQSEF PAVFLNFQDG DKVLEYIKNS HSPKARLEFQ VTHLGAKPAP
KVASYSSRGP SESCPFILKP DLMAPGALIL ASWPQKSPAT QIRSGELFSN FNIISGTSMS
CPHAAGVAAL LKGAHPKWSP AAIRSAMMTT ADAVDNTQMP IRDIGRNNNA ASPLAMGAGH
INPNKALDPG LIYDITSQDY NNLLCALNFT SQQIKSITRS SAYSCSNPSL DLNYPSFIGY
FNYNSSKSDP KRIQEFQRTV TNVGEGMSVY TAKLTSMDEY KVSVAPDKLV FKEKYEKQSY
KLRIEGPLLV DNYLVYGSLS WVETSGKYVV KSPIVATTIR VDPL
//
