ID A0A1U7YQW6_NICSY Unreviewed; 317 AA.
AC A0A1U7YQW6;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Nicotianamine synthase {ECO:0000256|RuleBase:RU368095};
DE EC=2.5.1.43 {ECO:0000256|RuleBase:RU368095};
GN Name=LOC104249606 {ECO:0000313|RefSeq:XP_009804361.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009804361.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009804361.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009804361.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Synthesizes nicotianamine, a polyamine which serves as a
CC sensor for the physiological iron status within the plant, and/or might
CC be involved in the transport of iron. {ECO:0000256|RuleBase:RU368095}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3 S-adenosyl-L-methionine = 3 H(+) + nicotianamine + 3 S-
CC methyl-5'-thioadenosine; Xref=Rhea:RHEA:16481, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17509, ChEBI:CHEBI:58249, ChEBI:CHEBI:59789; EC=2.5.1.43;
CC Evidence={ECO:0000256|RuleBase:RU368095};
CC -!- SIMILARITY: Belongs to the nicotianamine synthase (NAS)-like family.
CC {ECO:0000256|ARBA:ARBA00007009, ECO:0000256|RuleBase:RU368095}.
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DR RefSeq; XP_009804361.1; XM_009806059.1.
DR AlphaFoldDB; A0A1U7YQW6; -.
DR STRING; 4096.A0A1U7YQW6; -.
DR GeneID; 104249606; -.
DR KEGG; nsy:104249606; -.
DR eggNOG; ENOG502QTU6; Eukaryota.
DR OrthoDB; 2718460at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0030410; F:nicotianamine synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030418; P:nicotianamine biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR004298; Nicotian_synth.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR32266:SF11; NICOTIANAMINE SYNTHASE; 1.
DR PANTHER; PTHR32266; NICOTIANAMINE SYNTHASE 3; 1.
DR Pfam; PF03059; NAS; 1.
DR PROSITE; PS51142; NAS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW S-adenosyl-L-methionine {ECO:0000256|RuleBase:RU368095};
KW Transferase {ECO:0000256|RuleBase:RU368095}.
SQ SEQUENCE 317 AA; 35396 MW; AEC24B9B5F1C99E3 CRC64;
MVCQSNPVVE QVCELYEKIS KLESLNPSKD VNMLFTELVN TCMPPNPIDV SKLCQKIQEI
RSHLIKLCGE AEGLLESHYS KILGSYKNPL HHLNIFPYFD NYIKLSLLEF NILTKQTAIT
PARIAFVGSG PLPLTSLVLA TKHLKSTYFD NYDIDSAANS MASRLVASDP DLSQRMAFLS
IDIMDVTYAL KEYNVVFLAA LVGMDKEEKI KVINHLAKYM APGATLMLRS AHGARAFLYP
VVNSRDLKGF EVLSIYHPTD EVINSVVIAR KLPLQPLDQG FGSIVLPSKC ACAEIHSFNP
INKMNMIEEL SLEEQLS
//
