ID A0A1U7YTP1_NICSY Unreviewed; 656 AA.
AC A0A1U7YTP1;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Acetyl-coenzyme A synthetase {ECO:0000256|RuleBase:RU361147};
DE EC=6.2.1.1 {ECO:0000256|RuleBase:RU361147};
GN Name=LOC104247783 {ECO:0000313|RefSeq:XP_009802180.1,
GN ECO:0000313|RefSeq:XP_009802181.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009802180.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009802180.1, ECO:0000313|RefSeq:XP_009802181.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009802180.1,
RC ECO:0000313|RefSeq:XP_009802181.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate;
CC Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:456215; EC=6.2.1.1;
CC Evidence={ECO:0000256|RuleBase:RU361147};
CC -!- PATHWAY: Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene
CC biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step
CC 1/2. {ECO:0000256|ARBA:ARBA00004930}.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|RuleBase:RU361147}.
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DR RefSeq; XP_009802180.1; XM_009803878.1.
DR RefSeq; XP_009802181.1; XM_009803879.1.
DR GeneID; 104247783; -.
DR OrthoDB; 144557at2759; -.
DR UniPathway; UPA00372; UER00547.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR GO; GO:0009698; P:phenylpropanoid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU361147};
KW Ligase {ECO:0000256|RuleBase:RU361147};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU361147};
KW Phenylpropanoid metabolism {ECO:0000256|ARBA:ARBA00023051};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701}.
FT DOMAIN 139..199
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 207..594
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT REGION 56..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 656 AA; 73537 MW; EC19777305A3EEFF CRC64;
MEGRMTHHPL WNNNNNSTSG IYISASPIPI SRTAKSQLSR PWVSVKRPSF TFRFGGSPME
DPLTSSSSSS TTVSPRKNLT TSNHMRHVES MAKLPSGAGK ITRLNAVILG EALASEEDDL
VFPSENFSRQ AHVSSLQKYL EMYRRSVQDP AGFWSDIASE FYWREKWGQQ VYFENLDIRK
GKIQIEWFKG GMTNICYNCL DRNIESGNGD KIAIYWEGNE PGLDSSLTYN QLLARVCQLA
NYLKDIGVRK GDAVVIYLPM LMELPIAMLA CARIGAVHSV VFAGFSAESL AQRIMDCRPK
VVITCNAVMR GSKIIYLKEI VDRALMESAQ NGINTDVCLT YENESAMKKE MTKWIKGRDI
WWQDVIPKYP VTCDVEWVDA EDPLFLLYTS GSTGKPKGVL HTTGGYMVYT ATTFKYAFDY
KPTDIYWCTA DCGWITGHSY VTYGPLLNGA TVVIFEGAPS YPDAGRCWDI VDKFKVSIFY
TAPTLVRSLM REGDEHVSRY SRKSLRVLGS VGEPINPSAW RWFFNVVGDA RCPISDTWWQ
TETGGFMITP LPGAWPQKPG SATFPFFGVQ PVIVDEKGVE IEGECSGYLC VKSSWPGAFR
TLYGDHERYE ATYFSAFPGY YFSGDGCSRD KDGYCWLTGR VDDVINVSVV FAGSIL
//
