ID A0A1U7ZC52_NELNU Unreviewed; 1332 AA.
AC A0A1U7ZC52;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Lysine-specific demethylase REF6 isoform X1 {ECO:0000313|RefSeq:XP_010248779.1};
GN Name=LOC104591589 {ECO:0000313|RefSeq:XP_010248779.1};
GN ORFNames=HUJ06_009546 {ECO:0000313|EMBL:DAD30695.1};
OS Nelumbo nucifera (Sacred lotus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Proteales; Nelumbonaceae; Nelumbo.
OX NCBI_TaxID=4432 {ECO:0000313|Proteomes:UP000189703, ECO:0000313|RefSeq:XP_010248779.1};
RN [1] {ECO:0000313|EMBL:DAD30695.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:DAD30695.1};
RX PubMed=32343808;
RA Shi T., Rahmani R.S., Gugger P.F., Wang M., Li H., Zhang Y., Li Z.,
RA Wang Q., Van de Peer Y., Marchal K., Chen J.;
RT "Distinct Expression and Methylation Patterns for Genes with Different
RT Fates following a Single Whole-Genome Duplication in Flowering Plants.";
RL Mol. Biol. Evol. 37:2394-2413(2020).
RN [2] {ECO:0000313|RefSeq:XP_010248779.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; DUZY01000003; DAD30695.1; -; Genomic_DNA.
DR RefSeq; XP_010248779.1; XM_010250477.2.
DR STRING; 4432.A0A1U7ZC52; -.
DR GeneID; 104591589; -.
DR KEGG; nnu:104591589; -.
DR eggNOG; KOG1246; Eukaryota.
DR eggNOG; KOG1721; Eukaryota.
DR OrthoDB; 460721at2759; -.
DR Proteomes; UP000189703; Unplaced.
DR Proteomes; UP000607653; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0034647; F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR003349; JmjN.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR PANTHER; PTHR10694:SF38; LYSINE-SPECIFIC DEMETHYLASE REF6; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF02375; JmjN; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00545; JmjN; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS51183; JMJN; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Reference proteome {ECO:0000313|Proteomes:UP000189703};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 23..64
FT /note="JmjN"
FT /evidence="ECO:0000259|PROSITE:PS51183"
FT DOMAIN 193..359
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT DOMAIN 1239..1268
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1269..1298
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1299..1330
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 677..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1086..1145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1160..1207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..701
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1100..1118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1332 AA; 148604 MW; CFF66367889DE142 CRC64;
MAAVSAAESP PEIFPWLKTL PLAPEYHPTV AEFQDPIAYI LKIEKEASKF GICKIVPPLP
PPPKKTAIAN LNRSLAARSP NSNPKSPPTF TTRQQQIGFC PRKSRPVQKP VWQSGETYTL
QEFEAKAKQF EKTHLRKTGK KALSPLEIET LFWKASVDKP FSVEYANDMP GSAFVPVNGK
KWRESGEATT VGDTAWNMRG VSRAKGSLLR FMKEEIPGVT SPMVYIAMMF SWFAWHVEDH
DLHSLNYLHM GSAKTWYGVP REAAVAFEEV VRVHGYGGEV NPLVTFAILG EKTTVMSPEV
LVSLGIPCCR LVQNAGEFVV TFPRAYHSGF SHGFNCGEAA NIATPEWLKV AKEAAIRRAS
INYPPMVSHF QLLYSLALAL CSSIPTSIGT EPRSSRLKDK KRGEGDAMVK ELFVQNIMHN
NDLLHILLEK GSSCVLLPHS SDMSVCSNLR VGSQKKVKPR LPLSLCSPDE TMEASKDLLS
EDAMRERNAH LRHLSGFYSV KGKSSSVYGQ KSLHALCGND DLCSSTTEKQ STDTERESNV
KGDGLVDQGL FSCVTCGILT FACTAIIQPR EAAAQYLMST DCSVFNDWIV GSEVTSDRYT
VSVGDASMTG LNSCSDINSI PTFSYTGQMG KGGLYDVPVQ SGDYQFEVAG GSSKVAADAE
AQKGISSLDL LAVAYDSSDS EDDQDKTEKP VFSDENDFRD SSGELGSAQS DPPSKHKSPL
LPEPNHKDEA TSNTVSYVNE VSVQDYASER TPGRPSATFM NNQQSIDIPL ESDRENLVTL
ESNNSDDTYR DPLALSRRVV SRSVETCYRD GKLENSESGP QYRPSTSSNA ISNCLPLANL
AERAEFSDAD KSVKGKASSL MQRPDSDSSR LHIFCLEHAV EVEKQLHPIG GVHVLLLCHP
EYLKVEAEAK LLAEEMGIDY IWKDVPFREA TEEDQQRIRL ALDDDEVIPT NGDWAAKLGI
NLYYSAILSY TPFYSKQMPY NSVIYKAFGR SSPVNSPTKP KVSGKRPGKQ KKILVAGRWC
GKVWMSNQVH PFLGQIDDYE EELAKSYSTG AMPKEKPERK LDINCQEKPD FSEKKSSGGI
NTMVAKKSGR KRKRFEKGAI KKQKCLQREN HKATVDEPPE PDTPSGVKNL RTVRSGQMRQ
ETIRHRNDCE NNIRWEDSYE KDDLEGGPST RLRKRPPKKP SREVKEMMHE KQTKKKKAKK
APSNNEIDMK DEEAEYQCDM EGCTMGFSSK QELVLHKRNI CSVKGCGKKF FSHKYLVQHR
RVHMDDRPLK CPWKGCKMTF KWAWARTEHI RVHTGARPYV CHEPGCGQTF RFVSDFSRHK
RKTGHSVKKG KV
//
