ID A0A1U7ZIY8_NELNU Unreviewed; 2051 AA.
AC A0A1U7ZIY8;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Vacuolar protein sorting-associated protein 8 homolog isoform X2 {ECO:0000313|RefSeq:XP_010251529.1};
GN Name=LOC104593404 {ECO:0000313|RefSeq:XP_010251529.1};
OS Nelumbo nucifera (Sacred lotus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Proteales; Nelumbonaceae; Nelumbo.
OX NCBI_TaxID=4432 {ECO:0000313|Proteomes:UP000189703, ECO:0000313|RefSeq:XP_010251529.1};
RN [1] {ECO:0000313|RefSeq:XP_010251529.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS8 family.
CC {ECO:0000256|ARBA:ARBA00009422}.
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DR RefSeq; XP_010251529.1; XM_010253227.2.
DR GeneID; 104593404; -.
DR OrthoDB; 120292at2759; -.
DR Proteomes; UP000189703; Unplaced.
DR GO; GO:0006623; P:protein targeting to vacuole; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045111; Vps41/Vps8.
DR InterPro; IPR025941; Vps8_central_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR12616; VACUOLAR PROTEIN SORTING VPS41; 1.
DR PANTHER; PTHR12616:SF8; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG; 1.
DR Pfam; PF12816; Vps8; 1.
DR SMART; SM00320; WD40; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Reference proteome {ECO:0000313|Proteomes:UP000189703};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT REPEAT 588..629
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1860..1908
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 28..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1914..1933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2006..2033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2051 AA; 226557 MW; 5EEF57E55A41B01E CRC64;
MDEDLMMTEM LSRPSGDLDL DSFLQIHSSS DDDDLSGVPH RTVDEILNDS DSSSSSSSTL
FDSAAFRRGR FSNIPTSGNN LSSFPKEESQ IHDDDASVCS HESLSVSRIS IVDETLKSRE
ALNSAQLEEK SIDSNTSSLR RIRSDEPSGN TFSLGRSASR PFSPLFGGVK ANPKPGAALA
AAAAASRSIP TPHAAAIKSR RASSSIQRKL LHTEELDNSV GELNTFLDGN AHVDEPSHSG
GACDGFGSGI ILVGRKLSEE DEKVRKFPSS SAESIVLEFC GGDEVTENSH ESNEVSCLKD
MQIERAQASE SDGTGLLSQE NLSNLNSSTS TSIVEPQATS PIGTAEVLDT DEKSEISNST
NIKKENHPSF STNENAHKED LSSNVSDSIS LEKDIPSSPR YEKAKRLQDD LVVQGLGIHD
SEKSVSSDTK DGEVSFVGDD TSSRSGITEL VEDKFLQLES KRVSKKTAKK LRPSKKPLEL
AEELEKKHAS SGLHWEEGAA AQPMRLEGIR RGPPAVGYLH IDPDNAITRA ISSQAFRRDH
GSPQVLAVHA NFIAVGMSKG VIIVVPSKYS AHSADNMDYK MSILGAHGEK SHSPVTSMCF
NQQGDLLLAG YGDGHITVWD VQREAVAKVI TGGHTAPVVH TLFLGQDSQV TRQFKAVTGD
CKGLVLLHAF SVFPLFNKIT IKTQCLLDGQ RTGTVLTASP LLLYESHEGN PISAQGNATT
SASGIGSMMG GVVGGVVGGE AGWKILSEGS SLVDEGVVIF VTHQTALVAR LSPTLEVYAQ
LSKPDGVREG SMPYTAWKCM TQPQGSSTES FPGETFEKVS LLAIAWDRKI QVAKLVKSEL
KIYKEWTLDS VAIGVQWLDD QMLVVLTLRG QLCLFAKEGT ELHRTSFAVD GSGGVDIITY
HTYFTNVFGN PEKAYHNCVA ARGASIYMLG PMHLVVSRLL PWKERIQVLR RAGDWMGALD
MAMRLYDGHA HGVIDLPRTL DAIQETIMPY LVELLLSYVD EVFSYISVAF CNQIEKVEQV
NDPKSIRSSV HSEMEEQFAR VGGVAVEFCV HIKRIDILFD DIFSKFMAVK HGGTFLELLE
PYILKDMLGC LPPEIMQALV EHYSEKGWLQ RVEQCVLHMD ISSLDFNQVV RLCQEHGLYG
ALIYLFNRGL DDFKAPLEEL LQVLRNSQGD DAVAIGYRIL VYLKYCFSGL AFPPGHGSIP
PTRLPSLRAE LMQFLIEDSN DLNSEVVAGT KSSTGTCPNL YPLLLLDTEA TLQVISCAFL
EEEVPRSDHS FHGSDTNSED VKENDPKIES LDLMVQNTVD TLIHILDLEI SEVERSSGID
DTGYPEIWPS KKDMAHLLEF IAYFVACKQA TVSKSVLSHI LEYLTSESSL SLSVHHQKTE
TLKRREKHVI ALLKVVPETN WDSSYVLHLC EKAEFHQVCG LIHARRGQYI AALDSYLKDT
DEPIHAFSFI NDMLRLLRDT ESTQFQSAVI SRIPDLVNLS REGAFFLVIE HFNKEYHQIL
AGLRSHPKSL FLYLKTIIEI HLAGTLNFSS LEKGDNLDVS CGKRLKDHTN GHEAYLARIS
DFPKLLRQNP VHVTDEMIEL YLELLCQYER QSVLKFLETF ESYRVEHCLR LCQEYGVIDA
AAFLLERVGD VGSALLLTLS GLNEKFTILD AAVERIISDI PLSGTTEIEQ LNSVLRMEEV
DAIHDILQTS IGLCQRNTQR LDPNESESLW FHLLDSFCEP LKDSYDSQTA SEGGNHVSIL
AASFGTAEDK GASMNKWRIS NSHRGAHVLR RVISQFIRKI VEGMIGYVRL PTIMTKLLSD
NGGQEFGDFK LTILGMLGTY GFERRILVTA KSLIEDDTFY TMSLLKKGAS HGYAPQSLLC
CLCNSVLSKE SSSSSIRVFN CGHATHLQCE FQENEALEVG SSVGCPVCMP KKKSRQSRSK
SVHEDSGLVK SSLSRTQHAR GTTIIQHPYE PEALEKPYGL QQISRFEILN NLQKGKKSVQ
LENLPQLRLV PPAIYHEKVK KGMDIFAGES SSTPPKGEKP SKSKQFRELK MKGSTLRFPL
RSNIFEKRTK R
//
