ID A0A1U7ZPM0_NELNU Unreviewed; 582 AA.
AC A0A1U7ZPM0;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Protein DETOXIFICATION {ECO:0000256|RuleBase:RU004914};
DE AltName: Full=Multidrug and toxic compound extrusion protein {ECO:0000256|RuleBase:RU004914};
GN Name=LOC104592815 {ECO:0000313|RefSeq:XP_010250616.1};
OS Nelumbo nucifera (Sacred lotus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Proteales; Nelumbonaceae; Nelumbo.
OX NCBI_TaxID=4432 {ECO:0000313|Proteomes:UP000189703, ECO:0000313|RefSeq:XP_010250616.1};
RN [1] {ECO:0000313|RefSeq:XP_010250616.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199,
CC ECO:0000256|RuleBase:RU004914}.
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DR RefSeq; XP_010250616.1; XM_010252314.2.
DR AlphaFoldDB; A0A1U7ZPM0; -.
DR STRING; 4432.A0A1U7ZPM0; -.
DR GeneID; 104592815; -.
DR KEGG; nnu:104592815; -.
DR eggNOG; KOG1347; Eukaryota.
DR InParanoid; A0A1U7ZPM0; -.
DR OrthoDB; 36275at2759; -.
DR Proteomes; UP000189703; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR CDD; cd13136; MATE_DinF_like; 1.
DR InterPro; IPR044644; DinF-like.
DR InterPro; IPR002528; MATE_fam.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR42893:SF46; PROTEIN DETOXIFICATION 44, CHLOROPLASTIC; 1.
DR PANTHER; PTHR42893; PROTEIN DETOXIFICATION 44, CHLOROPLASTIC-RELATED; 1.
DR Pfam; PF01554; MatE; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|RuleBase:RU004914};
KW Reference proteome {ECO:0000313|Proteomes:UP000189703};
KW Transmembrane {ECO:0000256|RuleBase:RU004914};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004914}.
FT TRANSMEM 111..128
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 140..161
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 225..250
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 312..341
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 362..384
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 404..425
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 446..467
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 479..504
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 516..538
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 544..563
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT REGION 40..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 582 AA; 62328 MW; 30EF2F14F75B4BAD CRC64;
MSSCFSHPIP YACSLHQNCY CPYSTTSSCK SPTFRGNPNS TVRLQAIPRA SPRKNPASRL
ENPTRKSERQ VLREPIENQS PSPNMSSASS FFNLTTGLLH RLRDKLRVDE IALDILSIAL
PAALALAADP ITSLVDTAFV GHLGSVELAA VGVSISVFNL VSKLFNVPLL NITTSFVAEE
QALINDDNDL SPINGDEGFD SPSMPRERIG DKQDKKYLPA VSTSLALAAG IGISETIALS
IGSGFLMNIM GIPADSPMRL PAEHFLTLRA FGAPPMVIAL AAQGTFRGFL DTKTPLYAIS
AGNLLNAILD PILIFLFGFG IGGAAISTVI SEYLIAFILL WELNAKVLLI PPNMERMDVA
RYLTSGGLLI GRTIAVLLTM TLATSMAAQE GPIPMAGYQV CLQVWLAISL LNDALALSGQ
ALLAGDYSQG NYKQARHVVY RTLQSFGSIQ IGLVTGIALA VMLFIGFEAF SGLFSTDSAV
LGIARSGILF VAGSQPMNAL AFVLDGLYYG VSDFGYAAYS MVLVGLVSSV FLLIATPLYG
LSGVWAGLFL FMTLRVVAGF WRLSTKGGPW KMVWSEIDQK ND
//
