ID A0A1U7ZZE9_NELNU Unreviewed; 593 AA.
AC A0A1U7ZZE9;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Solute carrier family 40 member {ECO:0000256|RuleBase:RU365065};
GN Name=LOC104598758 {ECO:0000313|RefSeq:XP_010259256.1};
OS Nelumbo nucifera (Sacred lotus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Proteales; Nelumbonaceae; Nelumbo.
OX NCBI_TaxID=4432 {ECO:0000313|Proteomes:UP000189703, ECO:0000313|RefSeq:XP_010259256.1};
RN [1] {ECO:0000313|RefSeq:XP_010259256.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in iron transport and iron homeostasis.
CC {ECO:0000256|RuleBase:RU365065}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU365065}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU365065}.
CC -!- SIMILARITY: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A
CC subfamily. {ECO:0000256|ARBA:ARBA00006279,
CC ECO:0000256|RuleBase:RU365065}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_010259256.1; XM_010260954.2.
DR AlphaFoldDB; A0A1U7ZZE9; -.
DR GeneID; 104598758; -.
DR OrthoDB; 897443at2759; -.
DR Proteomes; UP000189703; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR CDD; cd17480; MFS_SLC40A1_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR009716; Ferroportin-1.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11660; SOLUTE CARRIER FAMILY 40 MEMBER; 1.
DR PANTHER; PTHR11660:SF53; SOLUTE CARRIER FAMILY 40 MEMBER 3, CHLOROPLASTIC; 1.
DR Pfam; PF06963; FPN1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|RuleBase:RU365065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365065};
KW Reference proteome {ECO:0000313|Proteomes:UP000189703};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365065};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365065};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365065}.
FT TRANSMEM 185..206
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 218..241
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 253..277
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 298..320
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 332..351
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 398..420
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 426..447
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 459..479
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 491..513
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 525..548
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 554..577
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
SQ SEQUENCE 593 AA; 63770 MW; C64809EEEF48EDB9 CRC64;
MGLVILSNSP SSPLLAISIR RASSPRSISR IRLRIASRHW LNKSAASLRQ GNFISRCSFT
NTDIHFNNVT TEEEIPDDLS SIPSGCSVPL VHIQSEILGT ESFNLLAEDS YMDSLLTTLP
VWLNIQPKCF DIMVLSEDEQ NALAATPAHP AGLYALYASC LAGNLTEQLW NFAWPAAVAL
IHPNLLPVAV VGFFTKLAIF VGGPLIGNLM DHFPRVPAFT FLSSIQAAAQ LLSVAMIIRA
HTIHTSFAPS MHIQPWFIVL VLAGAAERLS GLALGVAMER DWVVQLAGSN RPIALAQANA
ILSRIDLLCE IAGASLFGFL LSKYDPVTCL KLAAGLMICA LPIQILLTWL TNKLSTGVLD
RCKCQQTFGK ADAGNLGVDA IKNGWTEYKQ QPVLPASLAY VLLYFNIVLT PGGLMTAFLT
QRGLNPSIVG GFSGLCAFIG VAATFISANL VRRLGILKAG AAGLIFQASL LTLAVAVYWS
DSLSRQSSLL FFLSLIVLSR LGHMLYEVIG AQILQTGIPA SKANLIGTTE VSVASLAELV
MLGVAIIAND ASHFGFLAML SLSAVVGAAW MFCQWLANPT DEHRRLFSFD SQF
//
