ID A0A1U8A4X8_NELNU Unreviewed; 500 AA.
AC A0A1U8A4X8;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Xaa-Pro dipeptidase {ECO:0000256|ARBA:ARBA00044141};
DE EC=3.4.13.9 {ECO:0000256|ARBA:ARBA00044051};
DE AltName: Full=Imidodipeptidase {ECO:0000256|ARBA:ARBA00044351};
DE AltName: Full=Peptidase D {ECO:0000256|ARBA:ARBA00044252};
DE AltName: Full=Proline dipeptidase {ECO:0000256|ARBA:ARBA00044284};
GN Name=LOC104600769 {ECO:0000313|RefSeq:XP_010262206.1,
GN ECO:0000313|RefSeq:XP_010262207.1};
GN ORFNames=HUJ06_002698 {ECO:0000313|EMBL:DAD44468.1};
OS Nelumbo nucifera (Sacred lotus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Proteales; Nelumbonaceae; Nelumbo.
OX NCBI_TaxID=4432 {ECO:0000313|Proteomes:UP000189703, ECO:0000313|RefSeq:XP_010262206.1};
RN [1] {ECO:0000313|EMBL:DAD44468.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:DAD44468.1};
RX PubMed=32343808;
RA Shi T., Rahmani R.S., Gugger P.F., Wang M., Li H., Zhang Y., Li Z.,
RA Wang Q., Van de Peer Y., Marchal K., Chen J.;
RT "Distinct Expression and Methylation Patterns for Genes with Different
RT Fates following a Single Whole-Genome Duplication in Flowering Plants.";
RL Mol. Biol. Evol. 37:2394-2413(2020).
RN [2] {ECO:0000313|RefSeq:XP_010262206.1, ECO:0000313|RefSeq:XP_010262207.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + Xaa-L-Pro dipeptide = an L-alpha-amino acid + L-proline;
CC Xref=Rhea:RHEA:76407, ChEBI:CHEBI:15377, ChEBI:CHEBI:59869,
CC ChEBI:CHEBI:60039, ChEBI:CHEBI:195196; EC=3.4.13.9;
CC Evidence={ECO:0000256|ARBA:ARBA00043793};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the peptidase M24B family. Eukaryotic-type
CC prolidase subfamily. {ECO:0000256|ARBA:ARBA00043990}.
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DR EMBL; DUZY01000007; DAD44468.1; -; Genomic_DNA.
DR RefSeq; XP_010262206.1; XM_010263904.2.
DR RefSeq; XP_010262207.1; XM_010263905.2.
DR STRING; 4432.A0A1U8A4X8; -.
DR GeneID; 104600769; -.
DR KEGG; nnu:104600769; -.
DR eggNOG; KOG2737; Eukaryota.
DR OrthoDB; 1377484at2759; -.
DR Proteomes; UP000189703; Unplaced.
DR Proteomes; UP000607653; Unassembled WGS sequence.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd01087; Prolidase; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 1.
DR InterPro; IPR007865; Aminopep_P_N.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000994; Pept_M24.
DR PANTHER; PTHR48392; -; 1.
DR PANTHER; PTHR48392:SF2; PEPTIDASE D; 1.
DR Pfam; PF05195; AMP_N; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR SMART; SM01011; AMP_N; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000189703}.
FT DOMAIN 12..156
FT /note="Aminopeptidase P N-terminal"
FT /evidence="ECO:0000259|SMART:SM01011"
SQ SEQUENCE 500 AA; 56159 MW; 6413F6BFE7EBD53D CRC64;
MASPSSLSPP EVPMEMHAEN RAKLIKALRL HLSSSSRPLQ GFVFLQGGEE QTRYCTDHIE
LFRQESYFAY LFGVREPGFY GAIDIATGKS FLFAPRLDAD YAVWLGKIKP LSYFKEMYMV
NMVCYTDEIV GVLHDHYGGS GKPLLFLLHG LNTDSNKFSK PAQLEEMEKF DTDLSTLHPI
LIECRIIKSD LELALIQYAN DISSEAHVEV MRKARVDMKE YQLESIFLHH IYMYGGCRHC
SYTCICATGD NSAVLHYGHA AAPNDRTLND GDMALLDMGA EYHFYGSDIT CSFPVNGNFT
SDQLLIYNAV LKAHNTVISM MKPGVSWVNM HKLAERIILE SLKIEDLILG DVDDMMVERL
GAVFMPHGLG HFLGIDTHDP GGYAKGMERP KEPGLKALRT IRELQEGMVI TVEPGCYFID
ALLDPAMQSS NTSKFFNQEK ISRFKSFGGV RIESDVYVTC NGCKNLTKCP RETWEIEAVM
AGAPWPLDKI PAHTDNTRGR
//
