ID A0A1U8A6R3_NELNU Unreviewed; 270 AA.
AC A0A1U8A6R3;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Inorganic pyrophosphatase 1 {ECO:0000313|RefSeq:XP_010262202.1};
GN Name=LOC104600764 {ECO:0000313|RefSeq:XP_010262202.1};
OS Nelumbo nucifera (Sacred lotus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Proteales; Nelumbonaceae; Nelumbo.
OX NCBI_TaxID=4432 {ECO:0000313|Proteomes:UP000189703, ECO:0000313|RefSeq:XP_010262202.1};
RN [1] {ECO:0000313|RefSeq:XP_010262202.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946,
CC ECO:0000256|PIRSR:PIRSR031051-3};
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DR RefSeq; XP_010262202.1; XM_010263900.2.
DR AlphaFoldDB; A0A1U8A6R3; -.
DR STRING; 4432.A0A1U8A6R3; -.
DR GeneID; 104600764; -.
DR KEGG; nnu:104600764; -.
DR eggNOG; KOG3120; Eukaryota.
DR InParanoid; A0A1U8A6R3; -.
DR OrthoDB; 372892at2759; -.
DR Proteomes; UP000189703; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016791; F:phosphatase activity; IBA:GO_Central.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006384; HAD_hydro_PyrdxlP_Pase-like.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR016965; Pase_PHOSPHO-typ.
DR NCBIfam; TIGR01489; DKMTPPase-SF; 1.
DR NCBIfam; TIGR01488; HAD-SF-IB; 1.
DR PANTHER; PTHR20889:SF12; LP01149P; 1.
DR PANTHER; PTHR20889; PHOSPHATASE, ORPHAN 1, 2; 1.
DR Pfam; PF06888; Put_Phosphatase; 1.
DR PIRSF; PIRSF031051; PyrdxlP_Pase_PHOSPHO2; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
PE 4: Predicted;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|PIRSR:PIRSR031051-3};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR031051-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000189703}.
FT ACT_SITE 9
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR031051-1"
FT ACT_SITE 11
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR031051-1"
FT BINDING 9
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR031051-3"
FT BINDING 11
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR031051-3"
FT BINDING 20
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR031051-2"
FT BINDING 95
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR031051-2"
FT BINDING 176
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR031051-3"
SQ SEQUENCE 270 AA; 30586 MW; CBF19B4679F519E9 CRC64;
MAAVVVVFDF DKTIIDCDSD NWVIDEMGAT QLFDQLLPTM PWNPLMDRMM SEFHSQGKTI
EDIADCLRRA PLHPNIITAI KSAHALGCDL RIVSDANSFF IDTILKHHGL MDCFTEINTN
PSYVDDEGKL RIFPFHDFTS SPHSPCPPNM CKGLVIERIR ESVSAEGKKR FVYLGDGKGD
FCPALRLGEG EYVMPRKNFP LWELIHNNPL LVKAEVHEWS DGEELERILL QLINTILVEE
NNSLISVDCN FHTIPISTHE PLPKALPVHH
//
