ID A0A1U8AA87_NELNU Unreviewed; 588 AA.
AC A0A1U8AA87;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Protein HOTHEAD-like {ECO:0000313|RefSeq:XP_010262118.1};
GN Name=LOC104600715 {ECO:0000313|RefSeq:XP_010262118.1};
OS Nelumbo nucifera (Sacred lotus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Proteales; Nelumbonaceae; Nelumbo.
OX NCBI_TaxID=4432 {ECO:0000313|Proteomes:UP000189703, ECO:0000313|RefSeq:XP_010262118.1};
RN [1] {ECO:0000313|RefSeq:XP_010262118.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR RefSeq; XP_010262118.1; XM_010263816.2.
DR AlphaFoldDB; A0A1U8AA87; -.
DR STRING; 4432.A0A1U8AA87; -.
DR GeneID; 104600715; -.
DR KEGG; nnu:104600715; -.
DR eggNOG; KOG1238; Eukaryota.
DR InParanoid; A0A1U8AA87; -.
DR OrthoDB; 52047at2759; -.
DR Proteomes; UP000189703; Unplaced.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.30.410.40; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR45968; OSJNBA0019K04.7 PROTEIN; 1.
DR PANTHER; PTHR45968:SF5; PROTEIN HOTHEAD; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR000137-3};
KW FAD {ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR000137-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000189703};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..588
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010534030"
FT DOMAIN 288..302
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT BINDING 131
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 244
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 522..523
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 551
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 562..563
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT DISULFID 458..514
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-3"
SQ SEQUENCE 588 AA; 64208 MW; 2B773D32BA365FAF CRC64;
MASLGIVKLF LNIFFCLNLL ASSAQGKEDY SKYRYPFIKA ASSFTSSRTW TGNDSPYDYI
IVGGGTAGCP LAATLSEKFR VLLLERGDAP FANLNVSYLQ NFHISLADTS PTSASQAFIS
TDGVINARAR VLGGGTCINA GFYTRATPGF IKKAGWDSEI VKESYPWIEK QIVRWPQVAP
WQEALRNGLL EVGVSPFNGF TYDHIYGTKI GGTTFDKSGR RYTAAHLLAS ANPENLRVLV
HATVEKILFD KTGRQPRAVG VVFKDEYGNR HQAFVSKRME SEVILSSGAI GSPQLLLLSG
IGPATDLKRM NIPVVLHNEF VGKGMSDNPM NSIFVPTKKP VKQSLIETVG ITKMGVFIEG
SSGFGQSSDS IQCNHGIMSA EIGQLSTVPP KQRTPEAIKA YIESKQSLPH EAFMGGFVLE
KIVGPLSTGE LSLISTDVDD NPSVTFNYFS HPYDLKRCVY GIRMIEKVVQ TKHFADLINS
DMPAVEMLLN MSIKANVNLI PKQTNDTKSL EQFCKDTVTT IWHYHGGCHV GKVVDAKYKV
LGVDGLRVVD GSIFNTSPGT NPQATVMMMG RYMGVKILRE PLGRAAGV
//
