ID A0A1U8AIR4_NELNU Unreviewed; 1198 AA.
AC A0A1U8AIR4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Phospholipid-transporting ATPase {ECO:0000256|RuleBase:RU362033};
DE EC=7.6.2.1 {ECO:0000256|RuleBase:RU362033};
GN Name=LOC104600670 {ECO:0000313|RefSeq:XP_010262049.1};
OS Nelumbo nucifera (Sacred lotus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Proteales; Nelumbonaceae; Nelumbo.
OX NCBI_TaxID=4432 {ECO:0000313|Proteomes:UP000189703, ECO:0000313|RefSeq:XP_010262049.1};
RN [1] {ECO:0000313|RefSeq:XP_010262049.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate +
CC phospholipidSide 2.; EC=7.6.2.1;
CC Evidence={ECO:0000256|RuleBase:RU362033};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362033}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IV subfamily. {ECO:0000256|RuleBase:RU362033}.
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DR RefSeq; XP_010262049.1; XM_010263747.2.
DR AlphaFoldDB; A0A1U8AIR4; -.
DR GeneID; 104600670; -.
DR OrthoDB; 275833at2759; -.
DR Proteomes; UP000189703; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140326; F:ATPase-coupled intramembrane lipid transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015914; P:phospholipid transport; IEA:InterPro.
DR CDD; cd02073; P-type_ATPase_APLT_Dnf-like; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006539; P-type_ATPase_IV.
DR InterPro; IPR032631; P-type_ATPase_N.
DR InterPro; IPR032630; P_typ_ATPase_c.
DR NCBIfam; TIGR01652; ATPase-Plipid; 1.
DR PANTHER; PTHR24092:SF150; PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR24092; PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF16212; PhoLip_ATPase_C; 1.
DR Pfam; PF16209; PhoLip_ATPase_N; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362033};
KW Magnesium {ECO:0000256|RuleBase:RU362033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362033};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362033};
KW Reference proteome {ECO:0000313|Proteomes:UP000189703};
KW Translocase {ECO:0000256|RuleBase:RU362033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362033}.
FT TRANSMEM 86..104
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 110..127
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 306..327
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 359..380
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 917..934
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 946..966
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 996..1020
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 1032..1053
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 1065..1083
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 1103..1124
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT DOMAIN 44..111
FT /note="P-type ATPase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16209"
FT DOMAIN 882..1130
FT /note="P-type ATPase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16212"
SQ SEQUENCE 1198 AA; 135702 MW; B9DB80CBB0999EE6 CRC64;
MSRAGRARRK LRWSNLYTFS CLHPHVLESE GPHSLEGPGF SRIVYCNQSH LDQKKPLKYP
SNYISTTKYN VITFFPKAIF EQFRRVANLY FLMAAILSLT PIAPFSAVSM IAPLSFVVGL
SMAKEALEDW RRFIQDMKVN TRKVSMHKGD GTFCCIPWQK IQVGDVVRVE KDQFFPADLL
LLSSSYEDGI CYVETMNLDG ETNLKVKRSL EVTLPLDEDA DFKDFTGTIR CEDPNPSLYT
FVGNLEYDQR VYALDPSQIL LRDSKLRNTT HVYGVVIFTG HDSKVMQNAT KSPSKRSAVE
RKMDKIIYIL CTLLVLISLI SSIGFAVKTK FGMPDWWYLQ PEDTTNLYNP SKPMLSGTFH
LVTALILYGY LIPISLYVSI EVVKVLQAMF INQDINMYDE ETSNPAEART SNLNEELGQV
DTILSDKTGT LTCNQMDFLK CSIAGVAYGV GSSEVEIAAA KQMAFEEDAE ISGSMHNNND
HDSWENSVSD VSGSGIELQT VITSENEKEQ KPIIKGFGFE DKRLMDGNWL KEPNSDTILL
FFRILALCHT AIPELNEETG SFNYEAESPD EGAFLVAARE FGFEFCKRTQ TSVFIRERYP
SSEHPIEREF KILNLLEFSS KRKRMSVIVQ DENGEILLLC KGADSIIFDR LAKNGRTYLE
ETSRHLSEYG EAGLRTLALG YRKLEVAEYS NWNSEFLKAK TNVGGDREVM LEQVSDMMEK
DLILVGATAV EDKLQKGVPE CIDKLAQAGL KIWVLTGDKM ETAINIGYAC SLLRQGMKQI
CITMNTGSVA QDANKAAKED IMMQITNGSE MIKMEKDPDA AFALVIDGKT LAYALEDDIK
HQFLSLAVDC ASVICCRVSP KQKALEADIG VGISGVEGMQ AVMASDFSIA QFRFLQRLLV
VHGHWCYKRI SQMICYFFYK NILFGLTLFY FEAYTGFSGQ SVYDDWYMLL FNVILTSLPV
ISLGVFEQDV SSDVCLQFPA LYQQGPRNLF FDWYRIFGWM ANGFYSSLII FFPIISIFYN
QAFFSGGHTS DMAVVGTTMF TCVIWVVNCQ IALMMSHFTW IQHLLVWGSI FMWYLLLYLY
GMFSISGNAY QILVEVLAPA PIYWAITLLV TAACILPYLG YLSFQRCFNP MDHHVIQEIK
YYKKDVEDVH MWSRERSKAR QSTKIGFTAR VEAKIKQLRG KLHKKYPSIG VQTVISAS
//
