ID A0A1U8B338_NELNU Unreviewed; 807 AA.
AC A0A1U8B338;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=long-chain-alcohol oxidase {ECO:0000256|ARBA:ARBA00013125};
DE EC=1.1.3.20 {ECO:0000256|ARBA:ARBA00013125};
GN Name=LOC104610302 {ECO:0000313|RefSeq:XP_010275157.1};
OS Nelumbo nucifera (Sacred lotus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Proteales; Nelumbonaceae; Nelumbo.
OX NCBI_TaxID=4432 {ECO:0000313|Proteomes:UP000189703, ECO:0000313|RefSeq:XP_010275157.1};
RN [1] {ECO:0000313|RefSeq:XP_010275157.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Long-chain fatty alcohol oxidase involved in the omega-
CC oxidation pathway of lipid degradation.
CC {ECO:0000256|ARBA:ARBA00003842}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain primary fatty alcohol + O2 = a long-chain fatty
CC aldehyde + H2O2; Xref=Rhea:RHEA:22756, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16240, ChEBI:CHEBI:17176, ChEBI:CHEBI:77396; EC=1.1.3.20;
CC Evidence={ECO:0000256|ARBA:ARBA00000920};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR RefSeq; XP_010275157.1; XM_010276855.2.
DR AlphaFoldDB; A0A1U8B338; -.
DR STRING; 4432.A0A1U8B338; -.
DR GeneID; 104610302; -.
DR KEGG; nnu:104610302; -.
DR eggNOG; ENOG502QSD8; Eukaryota.
DR InParanoid; A0A1U8B338; -.
DR OrthoDB; 601859at2759; -.
DR Proteomes; UP000189703; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0046577; F:long-chain-alcohol oxidase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR InterPro; IPR012400; Long_Oxdase.
DR PANTHER; PTHR46056; LONG-CHAIN-ALCOHOL OXIDASE; 1.
DR PANTHER; PTHR46056:SF4; LONG-CHAIN-ALCOHOL OXIDASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF028937; Lg_Ch_AO; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRSR:PIRSR028937-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR028937-2};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189703};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 123..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 337..557
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00732"
FT DOMAIN 658..785
FT /note="Glucose-methanol-choline oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05199"
FT REGION 29..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 732
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR028937-1"
FT BINDING 290..305
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR028937-2"
SQ SEQUENCE 807 AA; 89235 MW; C8E0151052848C73 CRC64;
MNGNGAGKFS NFPTNGGVRH TVIDLGSIRT DPESKSTKAP NELHSPSLLP GERKPYVNSL
SPRQMEVLTA FSDTLLPSVF PDINCSGQLE DSLFKFYRTS ASMAGTPELV GGFLSGKIEH
PMLGVLLLAL WLLSTWFGTF ILCGIPSLST QFPYFQRFSQ VSQKKREKIL LSWSSSSFNI
YRMLFKTLKY LVFFIFFTQV DENNENPTWR GIDYCGPDPD FINNRTRETK TPQGHEHEEL
FEPLYRGIVN MRQPREALAE TLRQSGFHVR LHPHRRYNPS PSHPSLTIRC DAVVVGSGSG
GGVAAGILAK AGYKVAVLEK GNYFGRKNLS LLEGPSMDEM YLSGGLMVTD DMGVIMLAGS
TVGGGSTINW SASIRTPQHV IREWCNEYEL ELFGSKLYKE AMDVVCKRMG VQPDVEEESL
SNTVLRKGCS ELGYPVITAP RNSPPNHYCG WCCFGCKDGR KKGTSETWLV DLVDSGNGVI
LPGCEALKIL HERKKGRKRN TATGVVFEFN NGWGKDFCVL ESKVTIVAGG ALCTPTLLKR
SGLRNSNIGK NLHLHPVVMA WGHFPSRPAD SGWPEKDKKS YKGGIITAMS TVVANSEGSG
YGAVIQTPML HPGMFSVITP WISSVDMRER MSKFSRTAYI FALARDKGSG QVNSPSSISY
RMDAMDEEHL KQGLEKILRI LAAAGAEEIG TSHCLGRKVN VKKVSSNEFE RFVKKESRRA
LRDLRTPIPS AHQMGSCRMG VDPKSSVVNH RGETWEVEGL FLADSSVFPT ALGVNPMVTI
QSIAYCTAQS VLEVLRRKKD DLISFQF
//
