ID   A0A1U8B3B2_NELNU        Unreviewed;       935 AA.
AC   A0A1U8B3B2;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Exosome complex exonuclease RRP44 homolog A {ECO:0000313|RefSeq:XP_010270516.1};
GN   Name=LOC104606826 {ECO:0000313|RefSeq:XP_010270516.1};
OS   Nelumbo nucifera (Sacred lotus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Proteales; Nelumbonaceae; Nelumbo.
OX   NCBI_TaxID=4432 {ECO:0000313|Proteomes:UP000189703, ECO:0000313|RefSeq:XP_010270516.1};
RN   [1] {ECO:0000313|RefSeq:XP_010270516.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the RNR ribonuclease family.
CC       {ECO:0000256|ARBA:ARBA00005785, ECO:0000256|RuleBase:RU003901}.
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DR   RefSeq; XP_010270516.1; XM_010272214.2.
DR   AlphaFoldDB; A0A1U8B3B2; -.
DR   STRING; 4432.A0A1U8B3B2; -.
DR   GeneID; 104606826; -.
DR   KEGG; nnu:104606826; -.
DR   eggNOG; KOG2102; Eukaryota.
DR   InParanoid; A0A1U8B3B2; -.
DR   OrthoDB; 945235at2759; -.
DR   Proteomes; UP000189703; Unplaced.
DR   GO; GO:0000177; C:cytoplasmic exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0000176; C:nuclear exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IBA:GO_Central.
DR   GO; GO:0004519; F:endonuclease activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016075; P:rRNA catabolic process; IBA:GO_Central.
DR   CDD; cd09862; PIN_Rrp44-like; 1.
DR   Gene3D; 2.40.50.690; -; 1.
DR   Gene3D; 2.40.50.700; -; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR041505; Dis3_CSD2.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR002716; PIN_dom.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR022966; RNase_II/R_CS.
DR   InterPro; IPR033771; Rrp44_CSD1.
DR   InterPro; IPR033770; RRP44_S1.
DR   PANTHER; PTHR23355:SF35; EXOSOME COMPLEX EXONUCLEASE RRP44; 1.
DR   PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR   Pfam; PF17849; OB_Dis3; 1.
DR   Pfam; PF13638; PIN_4; 1.
DR   Pfam; PF00773; RNB; 1.
DR   Pfam; PF17216; Rrp44_CSD1; 1.
DR   Pfam; PF17215; Rrp44_S1; 1.
DR   SMART; SM00670; PINc; 1.
DR   SMART; SM00955; RNB; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE   3: Inferred from homology;
KW   Exonuclease {ECO:0000313|RefSeq:XP_010270516.1};
KW   Exosome {ECO:0000256|ARBA:ARBA00022835};
KW   Hydrolase {ECO:0000313|RefSeq:XP_010270516.1};
KW   Nuclease {ECO:0000313|RefSeq:XP_010270516.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189703};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          52..165
FT                   /note="PIN"
FT                   /evidence="ECO:0000259|SMART:SM00670"
FT   DOMAIN          471..802
FT                   /note="Ribonuclease II/R"
FT                   /evidence="ECO:0000259|SMART:SM00955"
FT   REGION          297..321
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   935 AA;  105003 MW;  4CAF50968C436263 CRC64;
     MLQSKSFVRK TKQGRVLKVV REHYLRDDIY CGASICKVCD SSAARLSSSA STILVVDTNV
     VLNQIDLLEN PAIDDVVVLS VVLEEVKNKN LSVYNRIRAL CSNSLRNFFV FSNEHHKDTY
     VKAMVGESPN DRNDRAIRVA TQWYQNHLGG SIRVLLITND KENKRKATEE GISAETVESY
     VKSLGQPNLL DLLVHPTSED VGMEEVEDLR PSKRKVIYSE HKPMSEITSG LHRGIYHQGK
     LRVNRYNPFE AYVGSESIGD EIIIYGRGNM NRAFDGDIVA VELLPRDQWQ EGKSLSIADD
     EDEEEEDVHL VPSSADDAPR NANVVQSSAG DVNPISCRPC GRVVGVIKRN WHSYCGSLEP
     MPMPAANGGV AHALFVSKDR RIPKIRIQTR QLGNLLDKRI IVAVDSWDCL SRYPSGHYVR
     TIGEIGDRDT ESEVVLIEND IDSRPFSAQV LACLPPLPWS LSSEDLANPN RQDLRHLRVF
     SVDPPGCKDI DDALHCTALS NGNFEVGVHI ADVTNFVHPG TPLDDEASQR GTSVYLVERR
     IDMLPKPLTE DICSLRSDVE RLAFSVIWEM TPQAEIISTR YTKSAIKSCA ALSYVEAQAR
     MDDSRLMDPL TTDLRNMNAL AKIMRLRRIE RGALTLASAE VKFQIDTETH DPLDIGMYQI
     REANQMVEEF MLAANVSVAE KILKHFPLCS LLRRHPIPTK EMLEPLLRTA VAVGLHLDVS
     SSKALADSLD HAIGDDPYFN KLIRILATRC MTQAVYFSSG DLTPPEFHHY GLAAPLYTHF
     TSPIRRYPDV IVHRLLAAAL GIYRLPPIFQ DRPQLTSIAD NLNYRHRNAQ MASRASVELH
     TLVYFRKRPT DTEARIVKIR SNGFIVFVPK YGIEGPVYLT ARGEKGGGEW FVDEEHQKVK
     KTDGSIIYSV LQTVRIHLEV VEPQPNRPKL QLTLI
//