ID A0A1U8B3S2_NELNU Unreviewed; 462 AA.
AC A0A1U8B3S2;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=cysteine desulfurase {ECO:0000256|ARBA:ARBA00012239};
DE EC=2.8.1.7 {ECO:0000256|ARBA:ARBA00012239};
GN Name=LOC104606959 {ECO:0000313|RefSeq:XP_010270720.1,
GN ECO:0000313|RefSeq:XP_010270721.1};
OS Nelumbo nucifera (Sacred lotus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Proteales; Nelumbonaceae; Nelumbo.
OX NCBI_TaxID=4432 {ECO:0000313|Proteomes:UP000189703, ECO:0000313|RefSeq:XP_010270720.1};
RN [1] {ECO:0000313|RefSeq:XP_010270720.1, ECO:0000313|RefSeq:XP_010270721.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the class-V pyridoxal-phosphate-dependent
CC aminotransferase family. NifS/IscS subfamily.
CC {ECO:0000256|ARBA:ARBA00006490}.
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DR RefSeq; XP_010270720.1; XM_010272418.2.
DR RefSeq; XP_010270721.1; XM_010272419.2.
DR STRING; 4432.A0A1U8B3S2; -.
DR GeneID; 104606959; -.
DR KEGG; nnu:104606959; -.
DR eggNOG; KOG1549; Eukaryota.
DR OrthoDB; 212394at2759; -.
DR Proteomes; UP000189703; Unplaced.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0031071; F:cysteine desulfurase activity; IBA:GO_Central.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0044571; P:[2Fe-2S] cluster assembly; IEA:InterPro.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR HAMAP; MF_00331; Cys_desulf_IscS; 1.
DR InterPro; IPR000192; Aminotrans_V_dom.
DR InterPro; IPR010240; Cys_deSase_IscS.
DR InterPro; IPR016454; Cysteine_dSase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR02006; IscS; 1.
DR PANTHER; PTHR11601:SF34; CYSTEINE DESULFURASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11601; CYSTEINE DESULFURYLASE FAMILY MEMBER; 1.
DR Pfam; PF00266; Aminotran_5; 1.
DR PIRSF; PIRSF005572; NifS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000189703}.
FT DOMAIN 65..426
FT /note="Aminotransferase class V"
FT /evidence="ECO:0000259|Pfam:PF00266"
SQ SEQUENCE 462 AA; 50853 MW; B970E021619335AB CRC64;
MTTKLFASKL RQTCNRGLIS HLRTLSVAAT ATAPTPSPLP LQEQQYEDAG EITMKGVKIS
GRPLYLDMQA TSPVDPRVLD AMLPFYLSRY GNPHSRTHLY GWESDIAVEK ARAQVAALIN
ASPKEIVFTS GATESNNISV KGVMHFYKDK KRHVITTQTE HKCVLDSCRH LQQEGFNVTY
LPVGSDGILD LDHLRSAIRP DTGLVSVMAV NNEIGVIQPV EEIGKICKEM NIPFHTDAAQ
ALGKIPIDVE KMDVSLMSLS GHKIYGPKGV GALYIRRRPR IRVEPQMNGG GQERGIRSGT
VPTPLVVGMG AACELAMKEM KYDEKRITAL QERLLNGIRA KLDGVAVNGS MERRYAGNLN
ISFAYVEGES LLMGLKEVAV SSGSACTSAS LEPSYVLRAL GVDEDMAHTS IRFGIGRFTT
ETEIDRAIEL TVQQVEKLRE MSPLYEMVKE GIDLKSIQWA QH
//
