ID A0A1U8B5H1_NELNU Unreviewed; 365 AA.
AC A0A1U8B5H1;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=4-hydroxy-tetrahydrodipicolinate synthase {ECO:0000256|ARBA:ARBA00012086};
DE EC=4.3.3.7 {ECO:0000256|ARBA:ARBA00012086};
GN Name=LOC104610990 {ECO:0000313|RefSeq:XP_010276183.1,
GN ECO:0000313|RefSeq:XP_010276197.1};
OS Nelumbo nucifera (Sacred lotus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Proteales; Nelumbonaceae; Nelumbo.
OX NCBI_TaxID=4432 {ECO:0000313|Proteomes:UP000189703, ECO:0000313|RefSeq:XP_010276197.1};
RN [1] {ECO:0000313|RefSeq:XP_010276183.1, ECO:0000313|RefSeq:XP_010276197.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde
CC [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
CC {ECO:0000256|ARBA:ARBA00003294}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-
CC hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O;
CC Xref=Rhea:RHEA:34171, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:67139, ChEBI:CHEBI:537519; EC=4.3.3.7;
CC Evidence={ECO:0000256|ARBA:ARBA00000594};
CC -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.
CC {ECO:0000256|ARBA:ARBA00005120}.
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|ARBA:ARBA00007592}.
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DR RefSeq; XP_010276183.1; XM_010277881.1.
DR RefSeq; XP_010276197.1; XM_010277895.1.
DR STRING; 4432.A0A1U8B5H1; -.
DR GeneID; 104610990; -.
DR KEGG; nnu:104610990; -.
DR eggNOG; ENOG502QQ8M; Eukaryota.
DR OrthoDB; 1780992at2759; -.
DR UniPathway; UPA00034; UER00017.
DR Proteomes; UP000189703; Unplaced.
DR GO; GO:0008840; F:4-hydroxy-tetrahydrodipicolinate synthase activity; IBA:GO_Central.
DR GO; GO:0019877; P:diaminopimelate biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniPathway.
DR CDD; cd00950; DHDPS; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR005263; DapA.
DR InterPro; IPR002220; DapA-like.
DR InterPro; IPR020625; Schiff_base-form_aldolases_AS.
DR InterPro; IPR020624; Schiff_base-form_aldolases_CS.
DR NCBIfam; TIGR00674; dapA; 1.
DR PANTHER; PTHR12128:SF15; 4-HYDROXY-TETRAHYDRODIPICOLINATE SYNTHASE 1, CHLOROPLASTIC; 1.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS00665; DHDPS_1; 1.
DR PROSITE; PS00666; DHDPS_2; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Diaminopimelate biosynthesis {ECO:0000256|ARBA:ARBA00022915};
KW Lysine biosynthesis {ECO:0000256|ARBA:ARBA00023154};
KW Reference proteome {ECO:0000313|Proteomes:UP000189703};
KW Schiff base {ECO:0000256|ARBA:ARBA00023270}.
SQ SEQUENCE 365 AA; 40213 MW; 5EADB16A23E134BA CRC64;
MSSLKSYGAS LRDATFQLPR LTGANNNKRR NGRWRSPEAA IIPNFHLPMR SLEVKNRTSA
EEIKSLRLIT AVKTPYLPDG RFDLEAYDAL MNMQIMNGVE GVIVGGTTGE GHLMSWDEHI
MLIGHTVNCF GGSIKVIGNT GSNSTREAIH ATEQGFAVGM HAALHINPYY GKTSLEGLVS
HFEAVLSMGP TIVYNVPSRT GQDIPPSVIH TVSQSANMAG VKECVGNDRI KEYTDEGVVV
WSGNDDQCHD ARWGYGATGV ISVTSNLVPG LMRELMFGGK NTCLNKKLMP LIEWLFREPN
PIGLNTALAQ LGVVRPIFRL PYVPLSLAKR VEFVEIVKQL GRENFVGERD VQVLDDDEFI
LVGRY
//
