UniProt: A0A1U8B950

Database: UniProt
Entry: A0A1U8B950_NELNU

LinkDB:  A0A1U8B950_NELNU 
Original site:  A0A1U8B950_NELNU

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Ontology (4)   
   GO (4)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (9)   
   InterPro (5)   
   Pfam (2)   
   PROSITE (1)   
   SMART (1)   
All databases (16)   

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ID   A0A1U8B950_NELNU        Unreviewed;       797 AA.
AC   A0A1U8B950;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN   Name=LOC104612053 {ECO:0000313|RefSeq:XP_010277685.1};
OS   Nelumbo nucifera (Sacred lotus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Proteales; Nelumbonaceae; Nelumbo.
OX   NCBI_TaxID=4432 {ECO:0000313|Proteomes:UP000189703, ECO:0000313|RefSeq:XP_010277685.1};
RN   [1] {ECO:0000313|RefSeq:XP_010277685.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC       {ECO:0000256|ARBA:ARBA00009476, ECO:0000256|RuleBase:RU361221}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU361221}.
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DR   RefSeq; XP_010277685.1; XM_010279383.2.
DR   AlphaFoldDB; A0A1U8B950; -.
DR   STRING; 4432.A0A1U8B950; -.
DR   GeneID; 104612053; -.
DR   KEGG; nnu:104612053; -.
DR   eggNOG; KOG0474; Eukaryota.
DR   InParanoid; A0A1U8B950; -.
DR   OrthoDB; 315083at2759; -.
DR   Proteomes; UP000189703; Unplaced.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015108; F:chloride transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR   CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR   CDD; cd03685; ClC_6_like; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   InterPro; IPR002251; Cl_channel_pln.
DR   PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR   PANTHER; PTHR11689:SF136; H(+)_CL(-) EXCHANGE TRANSPORTER 6; 1.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   PRINTS; PR01120; CLCHANNELPLT.
DR   SMART; SM00116; CBS; 2.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF81340; Clc chloride channel; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   3: Inferred from homology;
KW   CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW   ProRule:PRU00703}; Chloride {ECO:0000256|RuleBase:RU361221};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|RuleBase:RU361221};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189703};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361221};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT   TRANSMEM        66..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        116..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        232..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        267..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        319..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        450..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   DOMAIN          591..651
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   DOMAIN          705..762
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   797 AA;  88626 MW;  FB25704F93E11DE7 CRC64;
     MPSNHFQNGI EKAKHVWSRL PSSEEAEEQD GVELSRKRNG TNVESLDYEV IENYAYRKQQ
     AQRGRLYIGC YVAVKWFFAL LIGIGTGLAA VFINLAVENF AGWKFAATFS IIQSSYLAGF
     IVYILINLAL VFSSVYIVTQ FAPAAAGSGI PEIKGYLNGI DTHGVLLFRT LIGKIFGSIG
     SVGGGLALGK EGPLVHTGAC IASLLGQGGS TKYHLNSRWL HMFKSDRHRR DLVTCGCAAG
     VAAAFRAPVG GVLFALEEVT SWWRSQLMWR VFFTSAVVAV VVRTAMGWCK SGKCGHFGSG
     GFIIWDISGG QNDYSFEELL PMAVIGVIGG LLGALFNQLT LYITYWRRKY LHKKGNRVKI
     IEACLISLIT STISFGLPLL RKCSPCPKLE TNSSIECPRP PGMYGNYVNF YCKRDSEYND
     LATIFFNTQD DAIRNLFSAR TFHEYSAQSL LTFLVMFYTL AVVTFGTAVP AGQFVPEIMI
     GSTYGRLVGM FVVNFYKKLN IEEGTYALLG AASFLGGSMR MTVSLCVIMV EITNNLKFLP
     LIMLVLLISK AVGDAFNEGL YEMQARLRGI PLLESKPKYH MRKMKAKEAC RNQKVVYFPR
     VVKVADAVSI LRNSKHNGFP VVDQTKSGEA LVIGLILRSY LLVLLQSKVD FQHSHLPCAL
     RSGSIPIRHN ITEFAKPVSS KGISMDDIFL GPDDLEMYID LAPFLNPSPY IVPEDMSLAK
     VYYLFRQLGL RHIFVVPRAS HVVGLITRKD LLVEENEDPS TVELWSTIIR ARQHDKRVNR
     RRSEVENPLL DGLLVQE
//

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