ID   A0A1U8BCJ7_NELNU        Unreviewed;       561 AA.
AC   A0A1U8BCJ7;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Probable 28S rRNA (Cytosine-C(5))-methyltransferase isoform X1 {ECO:0000313|RefSeq:XP_010273967.1};
GN   Name=LOC104609368 {ECO:0000313|RefSeq:XP_010273967.1};
OS   Nelumbo nucifera (Sacred lotus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Proteales; Nelumbonaceae; Nelumbo.
OX   NCBI_TaxID=4432 {ECO:0000313|Proteomes:UP000189703, ECO:0000313|RefSeq:XP_010273967.1};
RN   [1] {ECO:0000313|RefSeq:XP_010273967.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
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DR   RefSeq; XP_010273967.1; XM_010275665.2.
DR   AlphaFoldDB; A0A1U8BCJ7; -.
DR   STRING; 4432.A0A1U8BCJ7; -.
DR   GeneID; 104609368; -.
DR   KEGG; nnu:104609368; -.
DR   eggNOG; KOG2360; Eukaryota.
DR   InParanoid; A0A1U8BCJ7; -.
DR   OrthoDB; 102852at2759; -.
DR   Proteomes; UP000189703; Unplaced.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0070475; P:rRNA base methylation; IBA:GO_Central.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR   InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR   InterPro; IPR049561; NSUN5_7_fdxn-like.
DR   InterPro; IPR048889; NSUN5_RCM1_N.
DR   InterPro; IPR023267; RCMT.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR22807:SF4; 28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR22807; NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR   Pfam; PF01189; Methyltr_RsmB-F; 1.
DR   Pfam; PF21148; NSUN5_fdxn-like; 1.
DR   Pfam; PF21153; NSUN5_N; 1.
DR   PRINTS; PR02008; RCMTFAMILY.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW   ProRule:PRU01023}; Reference proteome {ECO:0000313|Proteomes:UP000189703};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW   ProRule:PRU01023};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PROSITE-ProRule:PRU01023};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW   ProRule:PRU01023}.
FT   DOMAIN          155..469
FT                   /note="SAM-dependent MTase RsmB/NOP-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51686"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          475..498
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        403
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT   BINDING         244..250
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT   BINDING         268
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT   BINDING         295
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT   BINDING         341
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ   SEQUENCE   561 AA;  62858 MW;  77CD54D35561E809 CRC64;
     MRSSRLRPAV AKNVKGGRPS NADRSSYFAR REAAKVLRCV LHGDARRRAV ASIKSLVYSP
     CVRNKKATFA LVCQTLKHLP ILKDVLGATT ILNGKWKKQE ELIYVITYDI LFGQAIVLMG
     AAEKFLLLQK DALQSALAKL LVKKKVKQVE DLLLLYQTPE VTKPRYVRVN TLKLDVENAL
     CKLERQYMAR KDDMVPDLLV LPPGTDLHDH PLVMNGSVFL QGKASSMVAV ALRPKPGWEV
     LDACSAPGNK TVHLAALMKG QGKIIACELN KERVKRLEDT IKRSGATNVE VLHADFLNLN
     TKDPLYSKAW MVMIKFQLGG TKDLLAISSY VLREVRAILL DPSCSGSGTS ADRLDHLLPS
     YTAGQAADVA DTERVNKLAA FQRKALAHAL SFPAVERVVY STCSINQAEN EDVIKSVLPL
     AASHGFQLAT PFPQWPRRGF PVFEGSEHLL RTDPTIDMEG FFIALFVRKN VINGNQEKQK
     HRKPSKTTRT KNPFKNGSWT FLHQRRGGRN SLRPRKNVKN KITSTPLFFT RMSQIMLYPP
     VTGWGRTAQT THFVRRRIHI Q
//