ID A0A1U8BIW9_MESAU Unreviewed; 1348 AA.
AC A0A1U8BIW9;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000256|HAMAP-Rule:MF_03013};
GN Name=Cluh {ECO:0000313|RefSeq:XP_012967172.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012967172.1};
RN [1] {ECO:0000313|RefSeq:XP_012967172.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. Specifically binds mRNAs of nuclear-
CC encoded mitochondrial proteins in the cytoplasm and regulates transport
CC or translation of these transcripts close to mitochondria, playing a
CC role in mitochondrial biogenesis. {ECO:0000256|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03013}.
CC Cytoplasmic granule {ECO:0000256|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000256|HAMAP-
CC Rule:MF_03013}.
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DR RefSeq; XP_012967172.1; XM_013111718.2.
DR GeneID; 101843293; -.
DR CTD; 23277; -.
DR OrthoDB; 927222at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 3.30.2280.10; Hypothetical protein (hspc210); 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601:SF6; CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG; 1.
DR PANTHER; PTHR12601; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR Pfam; PF13424; TPR_12; 2.
DR SUPFAM; SSF103107; Hypothetical protein c14orf129, hspc210; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS51823; CLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_03013};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_03013}.
FT DOMAIN 373..615
FT /note="Clu"
FT /evidence="ECO:0000259|PROSITE:PS51823"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1303..1348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..67
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1303..1324
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1330..1348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1348 AA; 151047 MW; 35F1F2B587050EC6 CRC64;
MVIKTDELPA AAPADSAREH GSQAGGKGRP SSAEPPSVML LNGDCSDSFK KEEGTAKPPR
ENGLDEGEPG DETTGQEVIV IQDTGFSVKI LAPGIEPFSL QVSPQEMVQE IHQVLMDRED
TCHRTCFSLH LDGNMLDHFS ELRSVEGLQE GSVLRVVEEP YTVREARIHV RHVRDLLKSL
DPSDAFNGVD CNSLSFLSVF TDGDLGDSGK RKKGLEMDPI DCTPPEYILP GSRERPLCPL
QPQNRDWKPL QCLKVLTMSG WNPPPGNRKM HGDLMYLFVI TAEDRQVSIT ASTRGFYLNQ
STAYHFNPKP ASPRFLSHSL VELLNQISPT FKKNFAVLQK KRVQRHPFER IATPFQVYSW
TAPQAEHAMD CVRAEDAYTS RLGYEEHIPG QTRDWNEELQ TTRELPRKNL PERLLRERAI
FKVHSDFTAA ATRGAMAVID GNVMAINPSE ETKMQMFIWN NIFFSLGFDV RDHYKDFGGD
VAAYVAPTND LNGVRTYNAV DVEGLYTLGT VVVDYRGYRV TAQSIIPGIL ERDQEQSVIY
GSIDFGKTVV SHPRYLELLE RTSRPLKILR HRVLNDRDEE VELCSSVECK GIIGNDGRHY
ILDLLRTFPP DLNFLPVPGE ELPEECTRAG FPRAHRHKLC CLRQELVDAF VEHRYLLFMK
LAALQLMQQK ASKVETPTSL ENGGPPSSAE AESEDSVGPE AGSEEEGSSV SGLAKVKELA
ETIASDDGTD PRSREVIRNA CKAVGSISST AFDIRFNPDI FSPGVRFPES CQDEVRDQKQ
LLKDAAAFLL SCQIPGLVKD CTEHAVLPMD GATLAEVMRQ RGINMRYLGK VLDLVLRSPA
RDQLDHIYKI GIGELITRSA KHIFKTYLQG VELSGLSAAI SHFLNCFLSS YPNPVAHLPA
DELLSKKRNK RRKNRPPGAA DNTAWAVMTP QELWKNICQE AKNYFDFTLE CDSVDQAVET
YGLQKITLLR EISLKTGIQI LLKEYSFDSR HKPAFTEEDV LNIFPVVKHV NPKASDAFHF
FQSGQAKVQQ GFLKEGCELI NEALNLFNNV YGAMHVEICA CLRLLARLHY IMGDYAEALS
NQQKAVLMSE RVMGIEHPNT IQEYMHLALY CFASSQLSTA LSLLYRARYL MLLVFGEDHP
EMALLDNNIG LVLHGVMEYD LSLRFLENAL AVTTKYHGPK ALKVALSHHL VARVYESKAE
FRAALQHEKE GYTIYKTQLG EDHEKTRESS EYLKCLTQQA VALQRTMNEI YRNGSSANIP
PLKFTAPSMA SVLEQLNVIN GILFIPLSQK DLENLKAEVA RRHQLQEASR NRDKADDVAT
DPEPARAQQE DMGSPQTAKE DPSLSLQG
//
