ID A0A1U8BLR4_MESAU Unreviewed; 1319 AA.
AC A0A1U8BLR4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=Mink1 {ECO:0000313|RefSeq:XP_012967120.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012967120.1};
RN [1] {ECO:0000313|RefSeq:XP_012967120.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC protein kinase family. STE20 subfamily.
CC {ECO:0000256|ARBA:ARBA00008874}.
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DR RefSeq; XP_012967120.1; XM_013111666.2.
DR OrthoDB; 2904475at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR47096:SF1; CNH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47096; MISSHAPEN LIKE KINASE 1; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_012967120.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022777,
KW ECO:0000313|RefSeq:XP_012967120.1}.
FT DOMAIN 1..234
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1006..1293
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 244..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 892..929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..280
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..474
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..549
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..623
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..639
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..664
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..709
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..812
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 815..831
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 892..920
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1319 AA; 149138 MW; 705CC8A2799E2B1E CRC64;
MDVTEDEEEE IKQEINMLKK YSHHRNIATY YGAFIKKSPP GNDDQLWLVM EFCGAGSVTD
LVKNTKGNAL KEDCIAYICR EILRGLAHLH AHKVIHRDIK GQNVLLTENA EVKLVDFGVS
AQLDRTVGRR NTFIGTPYWM APEVIACDEN PDATYDYRSD IWSLGITAIE MAEGAPPLCD
MHPMRALFLI PRNPPPRLKS KKWSKKFTDF IDTCLIKTYL SRPPTEQLLK FPFIRDQPTE
RQVRIQLKDH IDRSRKKRGE KEETEYEYSG SEEEDDSHGE EGEPSSIMNV PGESTLRREF
LRLQQENKSN SEALKLQQQQ QQQQQQRDPE AHIKHLLHQR QRRIEEQKEE RRRVEEQQRR
EREQRKLQEK EQQRRLEDMQ ALRREEERRQ AEREQEYIRH RLEEEQRQLE ILQQQLLQEQ
ALLLEYKRKQ LEEQRQSERL QRQLQQEHAY LKSLQQQQQQ QQLQKQQQQQ QILPGDRKPL
YHYGRGINPA DKPAWAREVE ERARMNKQQN SPLAKTKPSS TGPEPPISQA SPSPPGPLSQ
TPPMQRPVEP QEGPHKSLVA HRVPLKPYAA PVPRSQSLQD QPTRNLAAFP ASHDPDPAAV
PTPTATPSAR GAVIRQNSDP TSEGPGPGPN PPSWVRPDNE APPKVPQRTS SIATALNTSG
AGGSRPAQAV RARPRSNSAW QIYLQRRAER GAPKPPGPPA PPPGPPSASS NPDLRRSDPG
WERSDSVLPA SHGHLPQAGS LERNRNRVEA STKLDSSPVL SPGNKAKPED HRSRPGRPAS
YKRAIGEDFV LLKERTLDEA PRPPKKAMDY SSSSEEVESS EDDDEEGDGE PSEGSRDTPG
GRSDGDTDSV STMVVHDVEE IAGNQPPYGG GTMVVQRTPE EERSLLLADS NGYTNLPDVV
QPSHSPTENS KGQSPPAKDG GSDYQSRGLV KAPGKSSFTM FVDLGLYQPG GSGDTIPITA
LVGGEGGRLD QLQFDVRKGS VVNVNPTNTR AHSETPEIRK YKKRFNSEIL CAALWGVNLL
VGTENGLMLL DRSGQGKVYG LIGRRRFQQM DVLEGLNLLI TISGKRNKLR VYYLSWLRNK
ILHNDPEVEK KQGWTTVGDM EGCGHYRVVK YERIKFLVIA LKNSVEVYAW APKPYHKFMA
FKSFADLPHR PLLVDLTVEE GQRLKVIYGS SAGFHAVDVD SGNSYDIYIP VHIQSQITPH
AIIFLPNTDG MEMLLCYEDE GVYVNTYGRI IKDVVLQWGE MPTSVAYICS NQIMGWGEKA
IEIRSVETGH LDGVFMHKRA QRLKFLCERN DKVFFASVRS GGSSQVYFMT LNRNCIMNW
//
