ID A0A1U8BPD9_MESAU Unreviewed; 2556 AA.
AC A0A1U8BPD9;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Striated muscle preferentially expressed protein kinase isoform X5 {ECO:0000313|RefSeq:XP_012969196.1};
GN Name=Speg {ECO:0000313|RefSeq:XP_012969196.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012969196.1};
RN [1] {ECO:0000313|RefSeq:XP_012969196.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
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DR RefSeq; XP_012969196.1; XM_013113742.2.
DR GeneID; 101837143; -.
DR CTD; 10290; -.
DR OrthoDB; 4215065at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 2.
DR CDD; cd20975; IgI_APEG-1_like; 1.
DR CDD; cd14108; STKc_SPEG_rpt1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR47633:SF7; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47633; IMMUNOGLOBULIN; 1.
DR Pfam; PF07679; I-set; 8.
DR Pfam; PF00069; Pkinase; 2.
DR Pfam; PF16650; SPEG_u2; 1.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 8.
DR SMART; SM00408; IGc2; 7.
DR SMART; SM00220; S_TKc; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 8.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 7.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Kinase {ECO:0000313|RefSeq:XP_012969196.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000313|RefSeq:XP_012969196.1}.
FT DOMAIN 23..111
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 171..260
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 265..359
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 366..454
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 490..580
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 587..684
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 787..875
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 903..1156
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1880..1970
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1977..2070
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2255..2507
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 108..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1210..1748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1760..1843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2050..2192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2204..2254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1466..1489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1490..1518
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1545..1568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1599..1613
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1629..1643
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1650..1665
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1760..1778
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1804..1837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2086..2109
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2110..2128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2156..2192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2206..2224
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2231..2251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 932
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 2556 AA; 278646 MW; 955285BB61FF8FF3 CRC64;
MSPELESSDD SYVSAGEEPL EAPVFEIPLQ NMVVAPGADV LLKCIITSNP PPQVSWKKDG
LTLYSEGRLL IRAEGERHTL LLREARAADA GSYTATATNE LGQASCASSL TVRPGGSTSP
LSSPITSDEE YLSPPEEFPE PGETWPRTPT MKLSPSQDRG DSSDSSSKAP PTFKVSLMDQ
SVREGQDVIM SIRVQGEPKP VVSWLRNRQP VRPDQRRFAE EAEGGLCRLR ILAAERGDAG
FYTCKAVNEY GARQCEARLE VRAHPESRSL AVLAPLQDVD VGAGEMALFE CLVAGPADVE
VDWLCRGRLL QPALLKCKMH FDGRKCKLLL TSVHEDDSGV YTCKLSTAKD ELTCSARLTV
RPSLAPLFTR LLEDVEVLEG RAARLDCKIS GTPPPSVTWT HFGHPVNESE NLRLQQDGGL
HSLHIARVGS EDEGLYEVSA TNTHGQAHCS AQLYVEEPRT AASGPSSKLE KMPSIPEEPE
HGDLERLSIP DFLRPLQDLE VGLAKEAMLE CQVTGLPYPA ISWFHNGHRI QSSDDRRMTQ
YRDIHRLVFP AVGPQHAGVY KSVIANKLGK AACYAHLYVT DVVPGPPDGA PQVVAVTGRM
VTLTWNPPRS LDMAIDPDSL TYTVQHQVLG SDQWTALVTG LRELEWAATG LKKGLQHIFR
VLSTSGKSSS KPSAPSEPVQ LVEHGPPLEE APAVLDKPDI VYVVEGQPAC ITVTFNHVEA
QVVWRSCRGA LLEARTGVYE LRQPDDDQYC LRICRVSRRD LGPLTCTARN RHGTKACSVT
LELAEAPRFE SIMEDVEVGP GETARFAVVA EGRPLPDIMW YKDEVLLAES NHVSFVYEEN
ECSLVVLSAG TEDGGVYTCT ARNLGGEVSC KAELSVRSAQ TAMEVEGVGE DEEHRGRRLS
DYYDIHQEIG RGAFSYLRRV VERSSGLEFA AKFIPSQAKP KVSARREARL LARLQHDCVL
YFHEAFERRR GLVIVTELCT EELLERMARK PTVCESETRA YMRQVLEGIC YLHQSHVLHL
DVKPENLLVW DGAGGEEQVR ICDFGNAQEL TPGEPQYCQY GTPEFVAPEI VNQSPVSGVT
DIWPVGVVAF LCLTGISPFV GENDRTTLMN IRNYNVAFEE TTFLSLSREA RGFLIKVLVQ
DRLRPTAEET LEHPWFKTQA KGAEVSTDHL KLFLSRRRWQ RSQISYKCHL VLRPIPELLR
APPERVWVAM PRRPPPSGGL SSSSDSEEEE LEELPSVPRP LQPEFSGSRV SLTDIPTEDE
ALGTPDTGAA TPMDWQEQGR APSKDQEAPS PEALPSPGQE PPDGPSPRRP ELRRGSSAES
ALPRVGSREP GRSLHKAASV ELPQRRSPSP GATRLTRGGL GEGEYAQRLQ ALRQRLLRGG
PEDGKVSGLR GPLLESLGGR ARDPRMARAA SSEAAPHHQP PPESRGLQKS SSFSQGEAEP
RGRHRRAGAP LEIPVARLGA RRLQESPSLS ALSEAQPPSP ARTSVPKPSI TKSPEPPAAT
PRDSPQPPSP QPAPEKVPEP KPEPVRAAKP AQPTLALQMP AQPLTPYAQI MQSLQLSGPT
QTLQDSTVPP LEPKPHAAVY ARVASGASDK RVPSARTPPV LPEKAPVPTV PPRPGSSLSG
SIENLESEAV FEAKFKRSRE SPLSRGLRLL SRSRSEERGP FRGAEDDGIY RPSPAGTPLE
LVRRPERSRS VQDLRVAGEP GLVRRLSLSL SQKLRRTPPG QRHPAWESRS GDGESSEGGS
SARGSPVLAV RRRLSSTLER LSSRLQRSGS SEDSGGASGR STPLFGRLRR ATSEGESLRR
LGVPHNQLAS QTGATTPSAE SLGSEASGTS GSSAPGESRS RHRWGLSRLR KNKGLSQPNL
SASVQEDLGH QYVPSESDFP PVFHIKLKDQ VLLEGEAATL LCLPAACPAP RISWMKDKQS
LRSEPSVVIV SCKDGRQLLS IPRAGKRHAG LYECSATNVL GSITSSCTVS VARIPGKLAP
PEVPQTYHDT ALVLWKPGDS RAPCTYTLER RVDGESVWHP VSSGILDCYY NVTQLPVGVT
VRFRVACSNR AGQGPFSNPS EKVLIRGPQD SSAQPAAAPQ DAPVTSGPAR APPPDSPTSL
APTPALAPPS PQAASLSSST SPVSASQALP SLRAMGPPPP TPPRKHRGLL AAQQAAPTPP
SIQITPSEPK SFVPDTGALT PTSTPQGVKP APSSTSLYMV TSFVSAPPAP EPPAPEPPPE
PTKVTVRSLS PAKEVVSSPT PESTTLRQGP PQKPYTFLEE KARGRFGVVR SCRENATGRT
FVAKIVPYAA EGKHRVLQEY EVLRTLHHER LMSLHEAYIT PRYLVLIAES CGNRELLCGL
SDRFRYSEDD VATYVVQLLQ GLDYLHGHHV LHLDIKPDNL LLAADNALKI VDFGSAQPYN
PQALKPLGHR TGTLEFMAPE MVKGDPIGSA TDIWGAGVLT YIMLSGYSPF YEPDPQETEA
RIVGGRFDAF QLYPNTSQSA TLFLRKVLSV HPWSRPSLQD CLVHPWLQDA YLMKLRRQTL
TFTTNRLKEF LGEQRRRRAE AATRHKVLLR SYPGSP
//
