ID   A0A1U8BS01_MESAU        Unreviewed;       720 AA.
AC   A0A1U8BS01;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Protein Hook homolog 3 isoform X1 {ECO:0000313|RefSeq:XP_012966293.1};
GN   Name=Hook3 {ECO:0000313|RefSeq:XP_012966293.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012966293.1};
RN   [1] {ECO:0000313|RefSeq:XP_012966293.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   -!- SIMILARITY: Belongs to the hook family.
CC       {ECO:0000256|ARBA:ARBA00006946}.
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DR   RefSeq; XP_012966293.1; XM_013110839.2.
DR   AlphaFoldDB; A0A1U8BS01; -.
DR   GeneID; 101822365; -.
DR   CTD; 84376; -.
DR   OrthoDB; 50921at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:InterPro.
DR   GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IEA:InterPro.
DR   CDD; cd22226; HkD_Hook3; 1.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR008636; Hook_C.
DR   InterPro; IPR043936; HOOK_N.
DR   PANTHER; PTHR18947; HOOK PROTEINS; 1.
DR   PANTHER; PTHR18947:SF38; PROTEIN HOOK HOMOLOG 3; 1.
DR   Pfam; PF05622; HOOK; 1.
DR   Pfam; PF19047; HOOK_N; 1.
DR   SUPFAM; SSF116907; Hook domain; 1.
DR   PROSITE; PS50021; CH; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT   DOMAIN          10..126
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   REGION          684..720
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          171..430
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          489..652
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        688..711
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   720 AA;  83389 MW;  0014D665C962C702 CRC64;
     MFNVESVERV ELCESLLTWI QTFNVDTPCQ TVEDLTNGVV MSQVLQKIDP VYFDDNWLNR
     IKTEVGDNWR LKISNLKKIL KGILDYNHEI LGQQINDFTL PDVNLIGEHS DAAELGRMLQ
     LILGCAVNCE QKQEYIQAIM MMEESVQHVV MTAIQELMSK ESPVSAGNDA YVDLDRQLKK
     TTEELNEALS AKEEIAQRCH ELDMQVAALQ EEKSSLLAEN QILMERLNQS DSIEDPNSPA
     GRRHLQLQTQ LEQLQEETFR LEAAKDDYRI RCEELEKEIS ELRQQNDELT TLADEAQSLK
     DEIDVLRHSS DKVSKLEGQV ESYKKKLEDL GDLRRQVKLL EEKNTMYMQN TVSLEEELRK
     ANAARGQLET YKRQVVELQN RLSDESKKAD KLDFEYKRLK EKVDGLQKEK DRLRTERDSL
     KETIEELRCV QAQEGQLTTQ GLMPLGSQES SDSLAAEIIT PEIREKLIRL QHENKMLKIN
     QEGSDNEKIA LLQSLLDDAN LRKNELETEN RLVNQRLLEV QSQVEELQKS LQDQGSKAED
     AISVLLKKKL EEHLEKLHEA NNELQKKRAI IEDLEPRFNN SSLRIEELQE ALRKKEEDMK
     QMEERYKKYL EKAKSVIRTL DPKQNQGAAP EIQALKNQLQ ERDRLFHSLE KEYEKTKSQR
     DMEEKYIVSA WYNMGMTLHK KAAEDRLAST GSGQSFLARQ RQATSTRRPY PGHVQPATAR
//