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Database: UniProt
Entry: A0A1U8BTU2_MESAU
LinkDB: A0A1U8BTU2_MESAU
Original site: A0A1U8BTU2_MESAU 
ID   A0A1U8BTU2_MESAU        Unreviewed;       617 AA.
AC   A0A1U8BTU2;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=Transcription factor 7-like 2 isoform X12 {ECO:0000313|RefSeq:XP_012969535.1};
GN   Name=Tcf7l2 {ECO:0000313|RefSeq:XP_012969535.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012969535.1};
RN   [1] {ECO:0000313|RefSeq:XP_012969535.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the TCF/LEF family.
CC       {ECO:0000256|ARBA:ARBA00006569}.
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DR   RefSeq; XP_012969535.1; XM_013114081.2.
DR   AlphaFoldDB; A0A1U8BTU2; -.
DR   GeneID; 101831174; -.
DR   CTD; 6934; -.
DR   OrthoDB; 5351131at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR   GO; GO:0009888; P:tissue development; IEA:UniProt.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd21996; HMG-box_TCF7-like; 1.
DR   Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR   Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR   InterPro; IPR027397; Catenin-bd_sf.
DR   InterPro; IPR013558; CTNNB1-bd_N.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR024940; TCF/LEF.
DR   PANTHER; PTHR10373; TRANSCRIPTION FACTOR 7 FAMILY MEMBER; 1.
DR   PANTHER; PTHR10373:SF32; TRANSCRIPTION FACTOR 7-LIKE 2; 1.
DR   Pfam; PF08347; CTNNB1_binding; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM01366; c-clamp; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; HMG-box; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00267};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00267}; Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT   DOMAIN          346..414
FT                   /note="HMG box"
FT                   /evidence="ECO:0000259|PROSITE:PS50118"
FT   DNA_BIND        346..414
FT                   /note="HMG box"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT   REGION          1..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          314..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          416..437
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          491..543
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          582..617
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..91
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        314..328
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        329..346
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        516..533
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        584..617
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   617 AA;  67734 MW;  3D067D7E6DF2533F CRC64;
     MPQLNGGGGD DLGANDELIS FKDEGEQEEK NSENSSAERD LADVKSSLVN ESETNQNSSS
     DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY PGYPFIMIPD LTSPYLPNGS
     LSPTARTLHF QPGSTHYSAY KTIEHQIAIQ YLQMKWPLLD VQAGSLQSRQ ALKDARSPSP
     AHIVSNKVPV VQHPHHVHPL TPLITYSNEH FTPGNPPPHL PADVDPKTGI PRPPHPPDIS
     PYYPLSPGTV GQIPHPLGWQ GQPVYPITTG GFRHPYPTAL TVNASMSRFP PHMVPPHHTL
     HTTGIPHPAI VTPTVKQESS QSDVGSLHSS KHQDSKKEEE KKKPHIKKPL NAFMLYMKEM
     RAKVVAECTL KESAAINQIL GRRWHALSRE EQAKYYELAR KERQLHMQLY PGWSARDNYG
     KKKKRKRDKQ PGETNEHSEC FLNPCLSLPP ITDLSAPKKC RARFGLDQQN NWCGPCRRKK
     KCVRYIQGEG SCLSPPSSDG SLLESPPPSP HLLGSPPQDA KSQTEQTQPL SLSLKPDPLA
     HLPMMPPPPA LLLAEAAHGK ASALCPNGAL DLPAAALQLP MVPSPSLAQP STSSLHSHGS
     LAGTQPQPLS LVTKSLE
//
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