ID   A0A1U8BUW9_MESAU        Unreviewed;       699 AA.
AC   A0A1U8BUW9;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Disks large homolog 4 isoform X5 {ECO:0000313|RefSeq:XP_012967079.1};
GN   Name=Dlg4 {ECO:0000313|RefSeq:XP_012967079.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012967079.1};
RN   [1] {ECO:0000313|RefSeq:XP_012967079.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_012967079.1; XM_013111625.2.
DR   AlphaFoldDB; A0A1U8BUW9; -.
DR   OrthoDB; 2879721at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0098978; C:glutamatergic synapse; IEA:UniProt.
DR   GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR   GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR   GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR   CDD; cd00071; GMPK; 1.
DR   CDD; cd00992; PDZ_signaling; 3.
DR   CDD; cd12030; SH3_DLG4; 1.
DR   Gene3D; 2.30.42.10; -; 3.
DR   Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR   InterPro; IPR016313; DLG1-like.
DR   InterPro; IPR019590; DLG1_PEST_dom.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR020590; Guanylate_kinase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR23119; DISCS LARGE; 1.
DR   PANTHER; PTHR23119:SF33; DISKS LARGE HOMOLOG 4; 1.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   Pfam; PF10608; MAGUK_N_PEST; 1.
DR   Pfam; PF00595; PDZ; 3.
DR   Pfam; PF10600; PDZ_assoc; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PIRSF; PIRSF001741; MAGUK_DLGH; 2.
DR   SMART; SM00072; GuKc; 1.
DR   SMART; SM00228; PDZ; 3.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR   PROSITE; PS50106; PDZ; 3.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          40..127
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          135..222
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          288..369
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          403..473
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          509..684
FT                   /note="Guanylate kinase-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50052"
SQ   SEQUENCE   699 AA;  77523 MW;  2F062BD426863896 CRC64;
     MDCLCIVTTK ANSPPVIVNT DTLEAPGYVN GTEGEMEYEE ITLERGNSGL GFSIAGGTDN
     PHIGDDPSIF ITKIIPGGAA AQDGRLRVND SILFVNEVDV REVTHSAAVE ALKEAGSIVR
     LYVMRRKPPA EKVMEIKLIK GPKGLGFSIA GGVGNQHIPG DNSIYVTKII EGGAAHKDGR
     LQIGDKILAV NSVGLEDVMH EDAVAALKNT YDVVYLKVAK PSNAYLSDSY APPDITTSYS
     QHLDNEISHS SYLGTDYPTA MTPTSPRRYS PVAKDLLGEE DIPREPRRIV IHRGSTGLGF
     NIVGGEDGEG IFISFILAGG PADLSGELRK GDQILSVNGV DLRNASHEQA AIALKNAGQT
     VTIIAQYKPE EYSRFEAKIH DLREQLMNSS LGSGTASLRS NPKRGFYIRA LFDYDKTKDC
     GFLSQALSFR FGDVLHVIDS SDEEWWQARR VHSDSETDDI GFIPSKRRVE RREWSRLKAK
     DWGSSSGSQG REDSVLSYET VTQMEVHYAR PIIILGPTKD RANDDLLSEF PDKFGSCVPH
     TTRPKREYEI DGRDYHFVSS REKMEKDIQA HKFIEAGQYN SHLYGTSVQS VREVAEQGKH
     CILDVSANAV RRLQAAHLHP IAIFIRPRSL ENVLEINKRI TEEQARKAFD RATKLEQEFT
     ECFSAIVEGD SFEEIYHKVK RVIEDLSGPY IWVPARERL
//