ID A0A1U8BWB8_MESAU Unreviewed; 972 AA.
AC A0A1U8BWB8;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Low-density lipoprotein receptor-related protein 8 isoform X3 {ECO:0000313|RefSeq:XP_012970405.1};
GN Name=Lrp8 {ECO:0000313|RefSeq:XP_012970405.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012970405.1};
RN [1] {ECO:0000313|RefSeq:XP_012970405.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_012970405.1; XM_013114951.2.
DR AlphaFoldDB; A0A1U8BWB8; -.
DR GeneID; 101836610; -.
DR CTD; 7804; -.
DR OrthoDB; 3918101at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 6.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 7.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF3; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 8; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 7.
DR Pfam; PF00058; Ldl_recept_b; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 7.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 7.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 7.
DR PROSITE; PS51120; LDLRB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|RefSeq:XP_012970405.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_012970405.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..972
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010573848"
FT TRANSMEM 834..857
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 385..424
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 471..517
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 518..560
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 561..604
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 605..649
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 773..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 44..56
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 51..69
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 63..78
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 83..95
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 90..108
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 145..160
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 164..176
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 171..189
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 183..198
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 262..280
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 274..289
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 295..307
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 302..320
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 314..329
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 389..399
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 972 AA; 107439 MW; E571259EE1E07C20 CRC64;
MGRPEWCALW PLALLLLLLL LLQLQHLSAA DPLPGGGQEP AKECEEDQFR CRNDRCIPSV
WRCDEDNDCS DNSDEDDCPK RTCADSDFTC DNGHCIPERW KCDGEEECPD GSDESKATCY
REECPAEKLS CGPGSQKCVP ASWRCDGEKD CEGGADEAGC PTLCAPHEFQ CSNRSCLASV
FVCDGDDDCG DGSDERGCSD PACPPREFRC GGGGTCIPER WVCDGQFDCE DRSDEAAELC
GRVGQETMAT AAACVPTTQF TCRSGECIHL GWRCDGDRDC KDKSDEADCS ASGPCSENDF
QCGDGTCVLA IKRCNQEHDC PDGSDEAGCL QVAPAFQRNR RRPRGLNECL HNNGGCSHIC
TDLKIGFECT CPTGFQLLDQ KTCGDIDECQ DPDACSQICV NYKGYFKCEC HPGYEMDSLT
KNCKAVAGKS PSLIFTNRHE VRKIDLVKRD YSRLIPMLKN VVSLDVEVAT NRIYWCDLSY
RKIYSAHMDK ASVPEEQVVL IDEQLHSPEG LAVDWVHKHI YWTDSGNKTI SVATVDGRRR
CTLFSRELSE PRAIAVDPLR GFMYWSDWGF QAKIEKSGLN GADRQTLVSD NIEWPNGITL
DLLSQRLYWV DSKLHQLSSI DFNGGNRKML IFSTDVLSHP FGIAVFEDKV FWTDLENEAI
FSANRLNGLE ISILAENLNN PHDIVIFHEL KQPTAADACE LSAQPNGGCE YLCLPAPQTS
NHSPKYTCAC PDTMWLGPDM KRCYRAPQST STTTLASAMT RTVLATTRAT GTTIHDPTYQ
NHSTETPNWT ATVPNSVSVP RAPSISPSTL SPATSNHSQH YGNEGSQMGS TVTAAVIGII
VPIVVIALLC MSGYLIWRNW KRKNTKSMNF DNPVYRKTTE EEDEDELHIG RTAQIGHVYP
AAISSFDRPL WAEPCLGETR DLEDPAPALK ELFVLPGEPR SQLHQLPKNP LSELPVVKCK
RVALSLEDDG LP
//
