ID A0A1U8BWI5_MESAU Unreviewed; 123 AA.
AC A0A1U8BWI5;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Potassium voltage-gated channel subfamily E member 2 {ECO:0000256|ARBA:ARBA00039513};
DE AltName: Full=MinK-related peptide 1 {ECO:0000256|ARBA:ARBA00041657};
DE AltName: Full=Minimum potassium ion channel-related peptide 1 {ECO:0000256|ARBA:ARBA00042904};
DE AltName: Full=Potassium channel subunit beta MiRP1 {ECO:0000256|ARBA:ARBA00042937};
GN Name=Kcne2 {ECO:0000313|RefSeq:XP_012971617.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012971617.1};
RN [1] {ECO:0000313|RefSeq:XP_012971617.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00037861}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00037861}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the potassium channel KCNE family.
CC {ECO:0000256|ARBA:ARBA00005688}.
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DR RefSeq; XP_012971617.1; XM_013116163.2.
DR AlphaFoldDB; A0A1U8BWI5; -.
DR STRING; 10036.ENSMAUP00000001098; -.
DR GeneID; 101826529; -.
DR KEGG; maua:101826529; -.
DR CTD; 9992; -.
DR eggNOG; ENOG502S1GJ; Eukaryota.
DR OrthoDB; 5361427at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
DR GO; GO:0005251; F:delayed rectifier potassium channel activity; IEA:Ensembl.
DR GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:Ensembl.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:Ensembl.
DR GO; GO:0044325; F:transmembrane transporter binding; IEA:Ensembl.
DR GO; GO:1902282; F:voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; IEA:Ensembl.
DR GO; GO:0071466; P:cellular response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:1901800; P:positive regulation of proteasomal protein catabolic process; IEA:Ensembl.
DR GO; GO:0097623; P:potassium ion export across plasma membrane; IEA:Ensembl.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IEA:Ensembl.
DR GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR GO; GO:1901379; P:regulation of potassium ion transmembrane transport; IEA:Ensembl.
DR GO; GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IEA:Ensembl.
DR InterPro; IPR000369; K_chnl_KCNE.
DR InterPro; IPR005425; K_chnl_volt-dep_bsu_KCNE2.
DR PANTHER; PTHR15282; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1, 3; 1.
DR PANTHER; PTHR15282:SF8; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 2; 1.
DR Pfam; PF02060; ISK_Channel; 1.
DR PRINTS; PR01605; KCNE2CHANNEL.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 46..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 123 AA; 14351 MW; 9191134F5DF81F6F CRC64;
MATLANFTQT LEDVFRKIFI TYMDTWRKNT TAQEQALQAK VDAENFYYVI LYLMVMIGMF
SFIVVAILVS TVKSKRREHS QDPYHQYIVE DWQEKYKSQI LHLEESKATI HENMGATGFA
ASP
//
