UniProt: A0A1U8C218

Database: UniProt
Entry: A0A1U8C218_MESAU

LinkDB:  A0A1U8C218_MESAU 
Original site:  A0A1U8C218_MESAU

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Ontology (8)   
   GO (8)   
Gene (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (18)   
   InterPro (8)   
   Pfam (3)   
   PROSITE (4)   
   SMART (3)   
All databases (28)   

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ID   A0A1U8C218_MESAU        Unreviewed;      1843 AA.
AC   A0A1U8C218;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Unconventional myosin-Vb isoform X2 {ECO:0000313|RefSeq:XP_012973507.1};
GN   Name=Myo5b {ECO:0000313|RefSeq:XP_012973507.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012973507.1};
RN   [1] {ECO:0000313|RefSeq:XP_012973507.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC       ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR   RefSeq; XP_012973507.1; XM_013118053.2.
DR   STRING; 10036.ENSMAUP00000001293; -.
DR   GeneID; 101828471; -.
DR   CTD; 4645; -.
DR   eggNOG; KOG0160; Eukaryota.
DR   OrthoDB; 1094820at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0045179; C:apical cortex; IEA:Ensembl.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR   GO; GO:0016197; P:endosomal transport; IEA:Ensembl.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd15477; Myo5b_CBD; 1.
DR   CDD; cd01380; MYSc_Myo5; 1.
DR   Gene3D; 1.10.10.820; -; 1.
DR   Gene3D; 1.20.5.190; -; 3.
DR   Gene3D; 1.20.58.530; -; 1.
DR   Gene3D; 6.20.240.20; -; 1.
DR   Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR   Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR   InterPro; IPR002710; Dilute_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR037990; Myo5b_CBD.
DR   InterPro; IPR001609; Myosin_head_motor_dom.
DR   InterPro; IPR004009; Myosin_N.
DR   InterPro; IPR036103; MYSc_Myo5.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR13140; MYOSIN; 1.
DR   PANTHER; PTHR13140:SF356; UNCONVENTIONAL MYOSIN-VB; 1.
DR   Pfam; PF01843; DIL; 1.
DR   Pfam; PF00612; IQ; 6.
DR   Pfam; PF00063; Myosin_head; 1.
DR   PRINTS; PR00193; MYOSINHEAVY.
DR   SMART; SM01132; DIL; 1.
DR   SMART; SM00015; IQ; 6.
DR   SMART; SM00242; MYSc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51126; DILUTE; 1.
DR   PROSITE; PS50096; IQ; 6.
DR   PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR   PROSITE; PS51844; SH3_LIKE; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW   ProRule:PRU00782};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00782};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW   ProRule:PRU00782};
KW   Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW   ProRule:PRU00782};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00782}; Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW   Transport {ECO:0000256|ARBA:ARBA00022927}.
FT   DOMAIN          8..60
FT                   /note="Myosin N-terminal SH3-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51844"
FT   DOMAIN          69..762
FT                   /note="Myosin motor"
FT                   /evidence="ECO:0000259|PROSITE:PS51456"
FT   DOMAIN          1521..1798
FT                   /note="Dilute"
FT                   /evidence="ECO:0000259|PROSITE:PS51126"
FT   REGION          599..629
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          641..663
FT                   /note="Actin-binding"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT   REGION          1086..1120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          897..948
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1143..1259
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1328..1435
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        599..621
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1095..1120
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         163..170
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ   SEQUENCE   1843 AA;  213644 MW;  82C5E4F63CFE18E2 CRC64;
     MSYSELYTRY TRVWIPDPDE VWRSAELTKD YKEGDKTLQL RLEDDTILEY PINVQNNQVP
     FLRNPDILVG ENDLTALSHL HEPAVLHNLK VRFLESNHIY TYCGIVLVAI NPYEQLPIYG
     QDVIYAYSGQ NMGDMDPHIF AVAEEAYKQM ARDEKNQSII VSGESGAGKT VSAKYAMRYF
     ATVGGSASDT NIEDKVLASS PIMEAIGNAK TTRNDNSSRF GKFIEIGFDK KYHIIGANMR
     TYLLEKSRVV FQAEDERNYH IFYQLCAAAS LPEFKELALT CAEDFYYTSH GGNTTIEGVD
     DAEDFEKTRQ ALTLLGVRES HQLSIFKIIA SILHLGSVEI QSERDGDSCS IPPKDEHLSN
     FCHLLGVEHS QMEHWLCHRK LVTTSETYVK TMSLQQVVNA RNALAKHIYA QLFSWIVEHI
     NKALHSSLKQ HSFIGVLDIY GFETFEINSF EQFCINYANE KLQQQFNSHV FKLEQEEYMK
     EQIPWTLIDF YDNQPCIDLI EAKLGILDLL DEECKIPKGT DQNWAQKLYE RHSNSQHFQK
     PRMSNTAFIV IHFADKVEYL SDGFLEKNRD TVYEEQINIL KASKFPLVAD LFQDDKDSVP
     ATSTAKNRSS SKINVRSSRP PMKVSNKEHK KSVGFQFRTS LNLLMETLNA TTPHYVRCIK
     PNDEKLPFHF DPKRAVQQLR ACGVLETIRI SAAGYPSRWT YHDFFNRYRV LMKKRELANT
     DKKSICKSVL ESLIKNPDKF QFGRTKIFFR AGQVAYLEKL RADKFREATV MIQKTVRGWL
     QKVKYRRLKA ATLTLQRFYR GHLARRLAEH LRRTRAAIVF QKYYRMQRAR LAYQRVRRAV
     VIIQSFTRAM FVRRNYCQIL KEHKATIIQK YARGWMARRH FQQQRDAAIV IQCAFRRLKA
     KQELKALKIE ARSAEHLKRL NVGMENKVVQ LQRKIDDQNK EFKTLSEQLS AVTSTHAMEV
     EKLKKELAHY QQNQEADTSL QLQEEVQSLR TELQRAQSER RVLEDAHSRE NGELRKRVAD
     LEHENALLKD EKEYLNNQIL HQSKAESSQS SVEENLLMKK ELEEERSRYQ NLVKEYSLLE
     QRYENLRDEQ TPGHRKNPSN QSSLESDSNY PSISTSEIGD TEDALQQVEE IGVEKAAMDM
     TVFLKLQKRV RELEQERKKL QVQLEKEQQD SKKVQVEQQN GIDVDQDADL AYNSLKRQEL
     ESENKKLKND LNELRKAVAD QAMQDNSTHS SPDSYSLLLN QLKLANEELE VRKEEVLILR
     TQIMNTDQRR LSGKYMEPNI NARTSWPNSE KHVDQEDAIE AYHGVCQTNS KTEDWGYLNE
     DGELGLAYQG LKQVARLLEA QLQAQSLEHE EEVERLKAQV ETLKEEMDKQ QQTFCQTLLL
     SPEAQVEFGV QQEISRLTNE NLDFKELVEK LEKNERKLKK QLKIYMKKAQ ELEAAQALAQ
     SDRRHHELTR QVTVQRKEKD FQGMLEYHKE DEALLIRNLV TDLKPQMLSG TVPCLPAYIL
     YMCIRHADYT NDDLKVHSLL SSTINGIKKV LKKHNDDFEM TSFWLSNTCR FLHCLKQYSG
     DEGFMKQNTP KQNEHCLKNF DLTEYRQVLS DLSIQIYQQL IKIAEGLLQP MIVSAMLENE
     SIQALSGVRP TGYRKRSSSM VDGENSYCLE AIIRQMNSFH TVMCDQGLDP EIILQVFKQL
     FYMINAVTLN NLLLRKDACS WSTGMQLRYN ISQLEEWLRG KNLHQSGAVQ TMEPLIQAAQ
     LLQLKKKTPE DAEAICSLCT ALSTQQIVKI LNLYTPLNEF EERVTVSFIR TIQAQLQERN
     DPQQLLLDSK HVFPVLFPFN PSALTMDSIH IPACLSLEFL NEV
//

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