ID A0A1U8C2R1_MESAU Unreviewed; 528 AA.
AC A0A1U8C2R1;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=ETS translocation variant 5 isoform X1 {ECO:0000313|RefSeq:XP_012970058.1, ECO:0000313|RefSeq:XP_012970059.1};
GN Name=Etv5 {ECO:0000313|RefSeq:XP_012970058.1,
GN ECO:0000313|RefSeq:XP_012970059.1, ECO:0000313|RefSeq:XP_021083765.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012970058.1};
RN [1] {ECO:0000313|RefSeq:XP_012970058.1, ECO:0000313|RefSeq:XP_012970059.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR RefSeq; XP_012970058.1; XM_013114604.2.
DR RefSeq; XP_012970059.1; XM_013114605.2.
DR RefSeq; XP_021083765.1; XM_021228106.1.
DR STRING; 10036.ENSMAUP00000017701; -.
DR GeneID; 101826616; -.
DR CTD; 2119; -.
DR OrthoDB; 3915960at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR006715; ETS_PEA3_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF160; ETS TRANSLOCATION VARIANT 5; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF04621; ETS_PEA3_N; 2.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT DOMAIN 386..466
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 149..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..176
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 528 AA; 59647 MW; CB51FACEB44AA027 CRC64;
MDGFCDQQVP FMVPGKSRSD ECRGRPVIDR KRKFLDTDLA HDSEELFQDL SQLQEAWLAE
AQVPDDEQFV PDFQSDNWSL TEEAGPQQLA RAGITVVLHA PPPTKIKREL HSPSSELSSC
SHEQALGANY GEKCLYNYCA YDRKPPSGFK PLTPPSTPLS PTHQNPLFPP PQATLPTSAL
APGAGPVQGV GPAPTPHSLP EPGSQQQTFA VPRPPHQPLQ MPKMMPESQY PSEQRFQRQL
SEPCHPFPPQ SGVPGDNRPS YHRQMSEPIV PAAPPPLQGF KQEYHDPLYE HGVPGMPGPP
AHGFQSPMGI KQEPRDYCTD SEVPNCQSSY MRGGYFSSNH EGFTYEKDPR LYFDDTCVVP
ERLEGKVKQE PTLYREGPPY QRRGSLQLWQ FLVTLLDDPA NAHFIAWTGR GMEFKLIEPE
EVARRWGIQK NRPAMNYDKL SRSLRYYYEK GIMQKVAGER YVYKFVCDPD ALFSMAFPDN
QRPFLKAESE CPLTEEDTLP LTHFEDNPAY LLDMDRCSSL PYAEGFAY
//
