ID A0A1U8C3T2_MESAU Unreviewed; 456 AA.
AC A0A1U8C3T2;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Ribonuclease inhibitor {ECO:0000256|ARBA:ARBA00014554};
DE AltName: Full=Ribonuclease/angiogenin inhibitor 1 {ECO:0000256|ARBA:ARBA00032534};
GN Name=Rnh1 {ECO:0000313|RefSeq:XP_012973065.1,
GN ECO:0000313|RefSeq:XP_012973069.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012973065.1};
RN [1] {ECO:0000313|RefSeq:XP_012973065.1, ECO:0000313|RefSeq:XP_012973069.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG.
CC May play a role in redox homeostasis. {ECO:0000256|ARBA:ARBA00025561}.
CC -!- SUBUNIT: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
CC {ECO:0000256|ARBA:ARBA00011699}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_012973065.1; XM_013117611.2.
DR RefSeq; XP_012973069.1; XM_013117615.2.
DR GeneID; 101839513; -.
DR CTD; 6050; -.
DR OrthoDB; 55870at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd00116; LRR_RI; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR041302; LRR_RI_cap.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF15; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 14; 1.
DR Pfam; PF13516; LRR_6; 7.
DR Pfam; PF18779; LRR_RI_capping; 1.
DR SMART; SM00368; LRR_RI; 13.
DR SUPFAM; SSF52047; RNI-like; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706}.
SQ SEQUENCE 456 AA; 49962 MW; 2708C75E9B2FAF75 CRC64;
MSLDIQCEQL SDARWTELLP LIQQYQVVRL DDCGLTEVRC KDISSAIQAN PTLTELSLCT
NELGDAGVCL VLQGLQNPTC KIQKLSLQNC SLTEAGCRVL PDVLRSLPTL RELHLSDNPL
GDAGLKLLCE GLLDPQCRLE KLQLEYCNLT ATSCEPLASV FRVKPDFKEI VLSNNDLHEA
GVQMLCQGLK DSACQLESLK LENCGITSAN CKYLCDVVAS KASLQQLDLS SNKLGNAGIA
ALCSGLLLPS CRIRTLWLWE CDITAEGCKD LCRVLRTKPS LKELSLAGNE LKDEGAQLLC
ESLLEPGCQL ESLWIKTCSL TAACCSHLCS VLTKNRSLLE LQMSSNPLGD SGVLELCKAL
GQPDIVLRVL WLGDCDVTDN GCSSLATVLL ANRSLRELDL SNNCMGDTGV LRLIESLRQP
SCALQQLVLY DIYWTEEVED QLRALEEERP SLRVIS
//
