ID A0A1U8C3V3_MESAU Unreviewed; 472 AA.
AC A0A1U8C3V3;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Transcription factor EB isoform X3 {ECO:0000313|RefSeq:XP_005072448.1};
GN Name=Tfeb {ECO:0000313|RefSeq:XP_005072448.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005072448.1};
RN [1] {ECO:0000313|RefSeq:XP_005072448.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MiT/TFE family.
CC {ECO:0000256|ARBA:ARBA00008289}.
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DR RefSeq; XP_005072448.1; XM_005072391.3.
DR RefSeq; XP_012970463.1; XM_013115009.1.
DR AlphaFoldDB; A0A1U8C3V3; -.
DR GeneID; 101831663; -.
DR KEGG; maua:101831663; -.
DR CTD; 7942; -.
DR OrthoDB; 3061893at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0140367; P:antibacterial innate immune response; IEA:Ensembl.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IEA:Ensembl.
DR GO; GO:0006959; P:humoral immune response; IEA:InterPro.
DR GO; GO:0032418; P:lysosome localization; IEA:Ensembl.
DR GO; GO:0007040; P:lysosome organization; IEA:Ensembl.
DR GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd18927; bHLHzip_TFEB; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR024098; bHLHzip_TFEB.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR021802; MiT/TFE_C.
DR InterPro; IPR031867; MiT/TFE_N.
DR PANTHER; PTHR45776; MIP04163P; 1.
DR PANTHER; PTHR45776:SF5; TRANSCRIPTION FACTOR EB; 1.
DR Pfam; PF11851; DUF3371; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF15951; MITF_TFEB_C_3_N; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 233..286
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 350..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..385
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 472 AA; 52342 MW; 17E159EC5D77B274 CRC64;
MASRIGLRMQ LMREQAQQEE QRERMQQQAV MHYMQQQQQQ PQLGGPPTPA INTPVHFQSP
PPVPGDVLKV QSYLENPTSY HLQQSQHQKV REYLSETYGN KFAAHISPAQ GSPKPPPAAS
PGVRAGHVLS TSAGNSAPNS PMAMLHISSN PEKEFDDVID NIMRLDSVLG YINPEMQMPN
TLPLSSSHLN VYSGDPQVTA SLVGVTSSSC PADLTQKREL TDAESRALAK ERQKKDNHNL
IERRRRFNIN DRIKELGMLI PKANDLDVRW NKGTILKASV DYIRRMQKDL QRSRELENHS
RRLEMTNKQL WLRIQELEMQ ARVHGLPTTS PSGVNMAELA QQVVKQELPS EDGPGEALML
GPEVPDPEQM PTLPPQAPPP PAAQSPFHHL DFSHSLSFGG GGDEGPTGYH DPLGTEHGSP
FPNLSKKDLD LMLLDDSLLP LASDPLFSTM SPEASKASSR RSSFSMEEGD VL
//
