ID   A0A1U8C4I8_MESAU        Unreviewed;       518 AA.
AC   A0A1U8C4I8;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=UNC5C-like protein {ECO:0000313|RefSeq:XP_012970504.1};
GN   Name=Unc5cl {ECO:0000313|RefSeq:XP_012970504.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012970504.1};
RN   [1] {ECO:0000313|RefSeq:XP_012970504.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the unc-5 family.
CC       {ECO:0000256|ARBA:ARBA00009844}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_012970504.1; XM_013115050.2.
DR   AlphaFoldDB; A0A1U8C4I8; -.
DR   STRING; 10036.ENSMAUP00000005137; -.
DR   eggNOG; KOG1480; Eukaryota.
DR   OrthoDB; 5252769at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005042; F:netrin receptor activity; IEA:InterPro.
DR   GO; GO:0008233; F:peptidase activity; IEA:Ensembl.
DR   GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   Gene3D; 2.60.220.30; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR037936; UNC5.
DR   InterPro; IPR033772; UPA.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR   PANTHER; PTHR12582:SF41; UNC5C-LIKE PROTEIN; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF17217; UPA; 1.
DR   Pfam; PF00791; ZU5; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00218; ZU5; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS51145; ZU5; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          102..237
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|PROSITE:PS51145"
FT   DOMAIN          415..494
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   REGION          45..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   518 AA;  58136 MW;  4DC048A9EEB2571A CRC64;
     MSPQESSVYP SQLLLLVGIP VASAFLLVQC LLWRCSRWLP GACRRPGDQE ETVSPPTSLP
     EYEPPRQGPL QTLPEVAAFY QELYTPTRGQ TITRQLRHKL LVYSAREVDH RGGCLMLHDM
     GISLFIPPGA VAVGRQERVS LVLVWDLTDA PPLSHRQGLV SPVVACDPHG ASFLKPCTLT
     FKHCAQQPGQ ACAYNSNTSL LEAKKWRPLG RPGASISRDE CRILLSHFSL YTCILEAPLG
     QTARKWLQLA VFCSPLAPGQ THLQLRVYFL NNTPCALQWA IANEQPHGGR MRGPCQLFDF
     TGARADQCLQ LKYISEGWEN VDESSSQLVP HLHIWHGKCP FRSFCFRRKA ANENEDCSAL
     TNEIIVTMHT FQDGLENKYM EILRFQASEE ESWAVPPLVS QPPPCNRLPP ELFEQLQMLL
     EPNSVSGNDW RRLASHLGLC GMKIRFLSCQ RSPAAAILEL FEEQNGSLQE LHYLMTSMER
     LDCASAIQNY LNRTPRGSPA VIHGGAWENY SLELDEKL
//