ID A0A1U8C5T4_MESAU Unreviewed; 832 AA.
AC A0A1U8C5T4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X9 {ECO:0000313|RefSeq:XP_012970959.1};
GN Name=Pik3c2g {ECO:0000313|RefSeq:XP_012970959.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012970959.1};
RN [1] {ECO:0000313|RefSeq:XP_012970959.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR RefSeq; XP_012970959.1; XM_013115505.2.
DR AlphaFoldDB; A0A1U8C5T4; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IEA:InterPro.
DR GO; GO:0035005; F:1-phosphatidylinositol-4-phosphate 3-kinase activity; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05177; PI3Kc_C2_gamma; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR037707; PI3K-C2-gamma_dom.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR015433; PI_Kinase.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR PANTHER; PTHR10048:SF29; PHOSPHATIDYLINOSITOL 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 30..209
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 275..553
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 586..698
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 711..832
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 832 AA; 95340 MW; C1BB2E5CC9E3D670 CRC64;
MGWEPAFPTD PTDFPAAGWE YIKPDSEENR TDIEEPPREC LKHIARLSQK QTPLLLSGEK
RRYLWFYRFY CDNENSSLPL VLGSAPGWDE GTVSEMHAIL RRWTFSHPLE ALGLLTSSFP
DQDIREVAVR QLDNLLTDEL LECLPQLVQA VKFEWTLESP LVELLLRRSL QSIRVAHRLY
WLLREAQAED CFKSWYQKLS AALQFCVGEA LNDELSKEQK LVKLLGDIGE KVKSASDPQR
QDILKKEIGN LEEFFKDIKT CHLPLNPALS IKGIDRDACS YFTSNALPLK ITFINADPMG
ENIGVIFKAG DDLRQDMLVL QIIQVMDNIW LQEGLDMQMI IYRCLSTGKA QGLIEMVPDA
VTLAKIHLHS GLIGPLKENT IKKWFSQHNH LKEDYEKALR NFFYSCAGWC VVTFILGVCD
RHNDNIMLTK SGHMFHIDFG KFLGHAQTFG GIKRDRAPFI FTSEMEYFIT EGGKNTQHFQ
DFVELCCRAY NIVRKRSQLI LSLLEMMLHA GLPELSGTED LKYVYNNLRP QDTELEATSH
FTKKIKESLE CFPVKLNNLI HTLAQMPALS LAKPAPQTLP RESRILQKNR TIQRVTILGL
SKTHNNLYLI EVTLRDNRKS LTRKSFEQFS RLHSQIQKQF SSLALPEFPH WWHLPFTDAD
HKRITDLSHY MEEILNGSYE VANSDCVLNF FLSEHTQPTL EDSPVVDPGG KVPDHNPKVQ
LVMTYEDSKL TILVKHMKNI HLPDGSAPSA HVEIYLLPHP SEVRRRKTKS VPKCTDPTYN
EIVVYDEVLD LQGHVLMLIV KSKTVFVGAI NIQLCSVPFG EEKWYPLGNS IV
//
