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Database: UniProt
Entry: A0A1U8C612_MESAU
LinkDB: A0A1U8C612_MESAU
Original site: A0A1U8C612_MESAU 
ID   A0A1U8C612_MESAU        Unreviewed;       720 AA.
AC   A0A1U8C612;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   05-JUN-2019, entry version 18.
DE   SubName: Full=ral guanine nucleotide dissociation stimulator-like 3 isoform X2 {ECO:0000313|RefSeq:XP_012974891.1};
GN   Name=Rgl3 {ECO:0000313|RefSeq:XP_012974891.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012974891.1};
RN   [1] {ECO:0000313|RefSeq:XP_012974891.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (DEC-2018) to UniProtKB.
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DR   RefSeq; XP_012974891.1; XM_013119437.1.
DR   STRING; 10036.XP_005078582.1; -.
DR   GeneID; 101825592; -.
DR   CTD; 57139; -.
DR   Proteomes; UP000189706; Genome assembly.
DR   GO; GO:0008321; F:Ral guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; -; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR030750; RGL3.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   PANTHER; PTHR23113:SF220; PTHR23113:SF220; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000189706};
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-
KW   ProRule:PRU00168, ECO:0000256|SAAS:SAAS01081641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT   DOMAIN       64    200       N-terminal Ras-GEF. {ECO:0000259|PROSITE:
FT                                PS50212}.
FT   DOMAIN      247    505       Ras-GEF. {ECO:0000259|PROSITE:PS50009}.
FT   DOMAIN      623    710       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   REGION       28     50       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1U8C612}.
FT   REGION      112    136       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1U8C612}.
FT   REGION      527    591       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1U8C612}.
FT   COILED      185    209       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    112    126       Pro-rich. {ECO:0000256|MobiDB-lite:
FT                                A0A1U8C612}.
FT   COMPBIAS    550    577       Pro-rich. {ECO:0000256|MobiDB-lite:
FT                                A0A1U8C612}.
SQ   SEQUENCE   720 AA;  79222 MW;  C7DAAFA74B142B97 CRC64;
     MERTAGKELA LAPLQGWGEE TEDGAVYSVS LRRQRSQRST PEGPGDDQAA IPAADTFLQY
     RTSKVRALRA ARLERLVHEL VSGDREQDPG FVPAFLATHQ AFVPTARVLG FLLPPPPPPP
     PPPGVDSKRA ERQDQSFSKN LRAVVSVLGS WLRDHPLDFR DPPAHQNLGS VRIFLDWAAP
     GGAEAREAEK LLEDFLEEAK REQAEEEQRL AWAGPLRAAQ SPRSEFVEDF EEEESHSSEG
     PELLDFSVDE VAEQLTLMDV ELFLRVRTCE CLGSMWSQRD RPGAAGISPT VRATVAQFNA
     VTSCVLGSVL ATPGLAASQR AQRIEKWIRI AQRCRELRNF SSLRAILSAL QSNPIYRLKR
     SWGAVSREAL STFRKLSQIF SDENNHLSCR AVLSQEETTE GPHDDGCLPG SLPSKLPPGP
     VPYLGTFLTD LVMLDTALPD MLKGNLINFE KRRKEWEILA RIQQLQQRCQ LYSLSPRPPV
     LAALRAQHQL SEEQSYRVSR VIEPPAASCP SSPRIRRRIS LTKCLSAKLS REKNPSPGGS
     PGDPSSPTSS VSPGSPPSSP RNRDPPPGSP PASPGPQGPT NKMSKAATST TPHCLQLSVN
     MDPPMTVSLS SSRIPLLGQQ TSEARVIRVS IDNNHGNLYR SILLTCQDKA PSVVQRALEK
     HNVPQPWARD YQLFQVLPGD RELLIPDSAN VFYAMSPAAP GDFLLRRKEG TRHTPSASPT
//
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