ID A0A1U8CC53_MESAU Unreviewed; 1408 AA.
AC A0A1U8CC53;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Enhancer of mRNA-decapping protein 4 {ECO:0000256|ARBA:ARBA00015762};
GN Name=Edc4 {ECO:0000313|RefSeq:XP_012973378.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012973378.1};
RN [1] {ECO:0000313|RefSeq:XP_012973378.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}.
CC -!- SIMILARITY: Belongs to the WD repeat EDC4 family.
CC {ECO:0000256|ARBA:ARBA00009639}.
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DR RefSeq; XP_012973378.1; XM_013117924.2.
DR GeneID; 101832553; -.
DR CTD; 23644; -.
DR OrthoDB; 2911539at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR Gene3D; 6.10.140.270; -; 1.
DR Gene3D; 1.10.220.100; conserved c-terminal region of ge- 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045152; EDC4-like.
DR InterPro; IPR049404; EDC4_C.
DR InterPro; IPR044938; EDC4_C_sf.
DR InterPro; IPR032401; EDC4_WD40.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR15598; ENHANCER OF MRNA-DECAPPING PROTEIN 4; 1.
DR PANTHER; PTHR15598:SF5; ENHANCER OF MRNA-DECAPPING PROTEIN 4; 1.
DR Pfam; PF21289; EDC4_C; 1.
DR Pfam; PF16529; Ge1_WD40; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 113..439
FT /note="Enhancer of mRNA-decapping protein 4 WD40 repeat
FT region"
FT /evidence="ECO:0000259|Pfam:PF16529"
FT REPEAT 292..325
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1275..1395
FT /note="Enhancer of mRNA-decapping protein 4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21289"
FT REGION 547..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 876..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 979..1029
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 929..943
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1408 AA; 152702 MW; 6B6B38B126288178 CRC64;
MASCASIDIE DATQHLRDIL KLDRPAGGSN AESRPSSAYN GDLNGLLVPD PLSSGDGNST
SKPGVRTMPP INLQEKQVIC LSGDDSSTCI GILAKEVEIV ASSDSSISSK ARGSNKVKIQ
PVAKYDWEQK YYYGNLIAVS NSFLAYAIRA ANNGSAMVRV ISVSTSERTL LKGFTGSVAD
LAFAHLNSPQ LACLDEAGNL FVWRLALVKG KIQEEILVHI RQPEGTPLNH FRRIIWCPFI
PEESEDCCEE SSPTVALLHE DRAEVWDLDM LRSSHNSWPV DVSQIKQGFI VVKGHSTCLS
EGALSPDGTV LATASHDGFV KFWQIYIEGQ DEPRCLHEWK PHDGRPLSCL LFCDNHKKQD
PEVPFWRFLI TGADQNRELK MWCTVSWTCL QTIRFSPDIF SSVSVPPSLK VCLDLSAEYL
ILSDVQRKVL YVMELLQNQD EGRACFSSIS EFLLTHPVLS FGIQVVSRCR LRHTEVLPAE
EENDSLGAES SHGASAMESA AGVLIKLFCV HTKALQDVQI RFQPQLNPDV VAPLPTHTAH
EDFTFPTAFG ESRPELGSEG LASGAHGSQP DLRRIVELPA PADFLSLSSE TKPKLMTPDA
FMTPTASLQQ ISASPSSSSS SSSSSSSSSS SSSSSLTAVS AVSSSSAMDP SLPSRPPEEL
TLSPKLQLDG SLTINSSSSL QASPRSLLPG LLPGPADKLT PKGPGQVSAA SALSLDLQEV
ESLGLPQASS SRTRSPDVIS SASTALSQDI PEIASEALSR GFGPSVPEGL IEPDSMASAA
SALHLLSPRP RQGPELGSQL GLDGGPGDGD RHNTPSLLEA ALTQEVATPD SQVWPTAPDI
TRETCSTLAE SPRNGLQEKH KSLAFHRPPY HLLQQHDSQD TSAEQSDHDD EVASLASASG
GFGSKIPTPR LPAKDWKTKG SPRTSPKLKR KSKKDDRDSA VGSRLTDHQV AEPPEDWPAL
IWQQQRELAE LWHNQEELLQ RLCAQLEGLQ NTVADHVERA LETRHEQEQR RLERALAEEQ
QRGGQLQEQL TQQLSQALSS AVAGRLERSI RDEIKKTVPP CVSRSLEPVA GQLSNSVATK
LTAVEGSMKE NISKLLKSKN VTDAIARAAA DTLQGPMQAA YREAFQSVVL PAFEKSCQAM
FQQINDSFRL GTQEYLQQLE SHMKSRKARE QEAREPVLAQ LRGLVSTLQS ATEQMAATVS
SSVRAEVQHQ LHVAVGSLQE SILAQVQRIV KGEVSVALKE QQATVTSSIM QAMRSAAGTP
VPSAHLDCQA QQAHILQLLQ QGHLNQAFQQ ALTAADLNLV LYVCETVDPA QVFGQPPCPL
SQPVLLSLIQ QLASDLGTRS DLKLSYLEEA VMHLDHSDPI TRDHMGSVMA QVRQKLFQFL
QADPHNSLGK AARRLSLMLH GLATPSLP
//
