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Database: UniProt
Entry: A0A1U8CFA1_MESAU
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Original site: A0A1U8CFA1_MESAU 
ID   A0A1U8CFA1_MESAU        Unreviewed;      1018 AA.
AC   A0A1U8CFA1;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   Name=Rps6kc1 {ECO:0000313|RefSeq:XP_012978092.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012978092.1};
RN   [1] {ECO:0000313|RefSeq:XP_012978092.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR   RefSeq; XP_012978092.1; XM_013122638.2.
DR   AlphaFoldDB; A0A1U8CFA1; -.
DR   GeneID; 101844326; -.
DR   CTD; 26750; -.
DR   OrthoDB; 5308056at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd02677; MIT_SNX15; 1.
DR   CDD; cd05576; STKc_RPK118_like; 1.
DR   Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR007330; MIT_dom.
DR   InterPro; IPR036181; MIT_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR035053; STK_RPK118-like.
DR   PANTHER; PTHR15508; RIBOSOMAL PROTEIN S6 KINASE; 1.
DR   PANTHER; PTHR15508:SF2; RIBOSOMAL PROTEIN S6 KINASE DELTA-1; 1.
DR   Pfam; PF04212; MIT; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF00787; PX; 1.
DR   SMART; SM00745; MIT; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF116846; MIT domain; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS50195; PX; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_012978092.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..1018
FT                   /note="non-specific serine/threonine protein kinase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010569176"
FT   DOMAIN          1..107
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   DOMAIN          722..1008
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          152..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          282..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          401..437
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          450..480
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          509..547
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          646..668
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          696..790
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        164..183
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        420..435
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1018 AA;  110322 MW;  7F4F8A0D304E4C40 CRC64;
     MLVLAKIPLL LAEEAAPATC MSIIVWKRYS DFKKLHKELW QIHRNLFRHS ELFPPFAKGI
     VFGRFDKTVI EERRQCAEDL LQFSANIPAL YNSKQLEDFF KGGIVNDGSA LIGPADEYPD
     SLPDTLPECG AEGFSSDSDL TSLTVDADSG AEVDDGMASW QGSPGRTVGL SLSADSSAAG
     PGASDSKASR AEDRESRSLF PSSLKPRLGR RDYLERAGQL IKLAVKKEEE DDYEAASDFY
     RKGVDLLLEG VQGESSPTRR EAVKRRTAEY LMRAESISSL RASPRLDSGL QPPGSLSSRP
     PWNLRSPAEE LKAFRVLGVI DKVLLVMDTR TEQTFILKGL RKSSECSRSR KTIIPRCVPN
     MVCLHKYIIS EESVFLVLQH AEGGKLWSYI SKFLNRSSQE SFDVKETKPR VPHRVYLQQP
     SASPPDSSSF ESRGSDMGGM LQVLPVKTSL TPSSQEDSNQ EDDGQDSSPR WPDSGSSSEE
     ECTAGYLTLC NEYGQEKIDL GSLNEEPIAL PGGGASADTQ AALSPLAGDR PSPSRQLKFS
     PGDEDPEAAC FPQTSDSLTM SKNSPMEFFR IDSKDSTSEL LGLDFGEKLH GLKPEPLRAL
     LTLADGEGGA EEAQDSISRG SDDSVPVISF KEAAFEGVCG AEEGRPDLLV NLPGEPQPTK
     EASAADPAKF AQASTGRLES KLFEAPDVLC LRLSSEQCHG PGKEDPEEPD DPAGSLPCGV
     TPKHQVQAGP GVLGTAVDDS SAGGHFLWPR SDPESEGLGR AEAAVTARDA GESPPHASSA
     HSGAKGRGAH ADTAAVEEVL LFTEQAKEEP SPLFQRDSET KEQSVLALGG EKEIHQIFED
     LDKKLAASSR FLIPEGCVQR WAAEMVVALD ALHREGIVCR DLNPNNILLN DGGHIQLTYF
     SRWSEVEDSC DSDAIARMYC APEVGAVTEE TAACDWWSLG AVLFELLTGK TLVECHPAGI
     NTHTTLNMPG CVSEEARSLI QQLLQFNPLE RLGAGVAGVE DIKSHPFFTP VDWAELTR
//
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