ID A0A1U8CHD3_MESAU Unreviewed; 1822 AA.
AC A0A1U8CHD3;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Receptor-type tyrosine-protein phosphatase F {ECO:0000256|ARBA:ARBA00044158};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=Ptprf {ECO:0000313|RefSeq:XP_012978857.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012978857.1};
RN [1] {ECO:0000313|RefSeq:XP_012978857.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28071753;
RA McCann K.E., Sinkiewicz D.M., Norvelle A., Huhman K.L.;
RT "De novo assembly, annotation, and characterization of the whole brain
RT transcriptome of male and female Syrian hamsters.";
RL Sci. Rep. 7:40472-40472(2017).
RN [2] {ECO:0000313|RefSeq:XP_012978857.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR RefSeq; XP_012978857.1; XM_013123403.2.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0051128; P:regulation of cellular component organization; IEA:UniProt.
DR CDD; cd00063; FN3; 7.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14629; R-PTP-F-2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF7; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 6.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 7.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_012978857.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1822
FT /note="Receptor-type tyrosine-protein phosphatase F"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010518845"
FT TRANSMEM 1165..1188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..123
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 135..230
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 238..320
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 327..417
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 422..516
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 520..610
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 615..723
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 724..817
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 822..914
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1267..1522
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1442..1513
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1554..1813
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1731..1804
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1822 AA; 203215 MW; D434DF902AB80428 CRC64;
MAPEPTPGRM MVPLVPALVM LGLMAGAHGD SKPVFVKVPE DQTGLSGGVA SFVCQATGEP
KPRITWMKKG KKVSSQRFEV IEFDDGAGSV LRIQPLRVQR DEAIYECTAT NSLGEINTSA
KLSVLEEDQL PSGFPTIDMG PQLKVVEKAR TATMLCAAGG TPDPEISWFK DFLPVDPTLS
NGRIKQLRSG GSPIRGALQI ESSEESDQGK YECVATNSAG TRYSAPANLY VRVRRVAPRF
SIPPSSQEVM PGGSVNLTCV AVGAPMPYVK WMMGAEELTK EDEMPVGRNV LELSNVMRSA
NYTCVAISSL GMIEATAQVT VKALPKPPID LVVTETTATS VTLTWDSGNA EPVSYYGIQY
RAAGTDGPFQ EVDGVATTRY SIGGLSPFSE YAFRVLAVNS IGRGPPSEAV RARTGEQAPS
SPPRRVQARM LSASTMLVQW EPPEEPNGLV RGYRVYYTPD SRRPLSAWHK HNTDAGLLTT
VGSLLPGITY SLRVLAFTAV GDGPPSPTIQ VKTQQGVPAQ PADFQAEAES DTRIQLSWLL
PPQERITKYE LVYWAAEDEG QQHKVTFDPT SSYTLEDLKP DTVYHFQLAA RSDLGVGVFT
PTIEARTAQS MPSGPPRKVE VEPLNSTAVH VSWKLPVPNK QHGQIRGYQV TYVRLENGEP
RGQPIIQDVM LAEAQWRPEE SEDYETTISG LTPETTYSIT VAAYTTKGDG ARSKPKVVTT
AGAVPGRPTM MVSTTAMHTA LLQWHPPKEL PGELLGYRLQ YRRADEARPN TIDFGKDDQH
FTVTGLHKGA TYIFRLAAKN RAGPGEEFEK EITTPEDVPS GFPQNLRVIG LTTSTTELAW
DPPVLAERNG RITNYTVVYR DINSQHELQN VTDDMHLTLF GLKPDTTYDI KVRAHTSKGA
GPLSPSIQSR TMPMEQVFAK NFRVAAAMKT SVLLSWEVPD SYKSAVPFKI LYNGQSVEVD
GHSMRKLIAD LQPNTEYSFV LMNRGSSAGG LQHLVSIRTA PDLLPNKPLP ASAFIEDGRF
SLSMPQVQEP SLVRWFYIVV VPIDRVGGNL LTPRWNTPEE LELDELLEAI EQGGEERRRR
RRQAERLKPY VAAQVDVLPD TFTLGDKKNY RGFYNRPLSP DLSYQCFVLA SLKEPMDQKR
YASSPYSDEI VVQVTPAQQQ EEPEMLWVTG PVLAVILIIL IVIAILLFKR KRTHSPSSKD
EQSIGLKDSL LAHSSDPVEM RRLNYQTPGS SAPSCPNISS MRDHPPIPIT DLADNIERLK
ANDGLKFSQE YESIDPGQQF TWENSNSEVN KPKNRYANVI AYDHSRVLLT SIDGVPGSDY
INANYIDGYR KQNAYIATQG PLPETMGDFW RMVWEQRTAT VVMMTRLEEK SRVKCDQYWP
ARGTETYGLI QVTLVDTVEL ATYTMRTFAL HKSGSSEKRE LRQFQFMAWP DHGVPEYPTP
ILAFLRRVKA CNPLDAGPMV VHCSAGVGRT GCFIVIDAML ERMKHEKTVD IYGHVTCMRS
QRNYMVQTED QYVFIHEALL EAAMCGHTEV PARNLYAHIQ KLGQVPPGES VTAMELEFKL
LANSKAHTSR FISANLPCNK FKNRLVNIMP YELTRVCLQP IRGVEGSDYI NASFLDGYRQ
QKAYIATQGP LAESTEDFWR MLWEHNSTII VMLTKLREMG REKCHQYWPA ERSARYQYFV
VDPMAEYNMP QYILREFKVT DARDGQSRTI RQFQFTDWPE QGVPKTGEGF IDFIGQVHKT
KEQFGQDGPI TVHCSAGVGR TGVFITLSIA LERMRYEGVV DMFQTVKTLR TQRPAMVQTE
DQYQLCYRAA LEYLGSFDHY AT
//
