ID A0A1U8CHM4_MESAU Unreviewed; 1182 AA.
AC A0A1U8CHM4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Phosphatidylcholine translocator ABCB4 isoform X3 {ECO:0000313|RefSeq:XP_012978956.1};
GN Name=Abcb4 {ECO:0000313|RefSeq:XP_012978956.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012978956.1};
RN [1] {ECO:0000313|RefSeq:XP_012978956.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC Multidrug resistance exporter (TC 3.A.1.201) subfamily.
CC {ECO:0000256|ARBA:ARBA00007577}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_012978956.1; XM_013123502.2.
DR AlphaFoldDB; A0A1U8CHM4; -.
DR OrthoDB; 5487044at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18578; ABC_6TM_Pgp_ABCB1_D2_like; 1.
DR CDD; cd03249; ABC_MTABC3_MDL1_MDL2; 2.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR43394:SF11; ALPHA-FACTOR-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR43394; ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 3.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 55..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 117..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 837..856
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 876..897
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 58..179
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 180..260
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 295..531
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 615..902
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 937..1175
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1182 AA; 130088 MW; F589F13DA5CB591A CRC64;
MDLEAARNGT ARRPGTLEGD FELGSISNQG RDKKKKVNLI GPLTLFRYSD WQDKLFMLLG
TIMAIAHGSG LPLMMIVFGE MTDKFVNNAG NFSLPVNFSL SMINPGRILE EEMTRYAYYY
SGLGGGVLVA AYIQVSFWTL AAGRQIKKIR QNFFHAILRQ EMGWFDIKGT TELNTRLTEY
QKHLENAKKI GIKKAISANI SMGIAFLLIY ASYALAFWYG STLVISKEYT IGNAMTVFFS
ILIGAFSVGQ AAPCIDAFAN ARGAAYVIFD IIDNNPKIDS FSESGHKPDS IKGNLDFSDV
HFSYPSRANI KILKGLNLKV QSGQTVALVG NSGCGKSTTV QLLQRLYDPT EGTISIDGQD
IRNFNVRYLR EIIGVVSQEP VLFSTTIAEN IRYGRGNVTM DEIKKAVKEA NAYEFIMKLP
QKFDTLVGER GAQLSGGQKQ RIAIARALVR NPKILLLDEA TSALDTESEA EVQAALDKAR
EGRTTIVIAH RLSTVRNADV IVGFEDGVIV EQGSHSELMQ KEGVYFRLVN MQTSGSQILS
EEFEVELREE KAASGMAPNG WKSHIFRNST KKSLKSSRVH QHRLDADANQ LDANVPPVSF
LKVLKLNKTE WPYFVVGTVC AIVNGALQPA ISIILSEMIA IFGPGDPAVK QQKCNLFSLV
FLGLGVLSFF TFFLQGFTFG KAGEILTTRL RSMAFKAMLR QDMSWFDDYK NSTGALSTRL
ATDAAQVQGA TGTRLALIAQ NTANLGTGII ISLIYGWQLT LLLLSVVPFI AVSGIVEMKM
LAGNAKREKK ALEAAGKIAT EAIENIRTVV SLTQERKFES MYVEKLHGPY RNSVQMAHIY
GITFSISQAF MYFSYAGCFR FGAYLIVNGH MRFRDVILVF SAIVFGAVAL GHASSFAPDY
AKAKLSAAHL FSLFERQPLI DSYSGEGLWP DKFEGSVTLN EVVFNYPTRP DIPVLQGLSL
EVKKGQTLAL VGSSGCGKST VVQLLERFYD PMAGTVLLDG QEAKKLNVQW LRAQLGIVSQ
EPILFDCSIA ENIAYGDNSR VVSQEEIVRA AKVANIHPFI ETLPQKYETR VGDKGTQLSG
GQKQRIAIAR ALIRQPRILL LDEATSALDT ESEKVVQEAL DKAREGRTCI VIAHRLSTIQ
NADLIVVIQN GKVKEHGTHQ QLLAQKGIYF SMVSVQAGAQ NS
//
