ID A0A1U8CIF3_MESAU Unreviewed; 798 AA.
AC A0A1U8CIF3;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Relaxin receptor 2 {ECO:0000313|RefSeq:XP_012978270.1};
GN Name=Rxfp2 {ECO:0000313|RefSeq:XP_012978270.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012978270.1};
RN [1] {ECO:0000313|RefSeq:XP_012978270.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR RefSeq; XP_012978270.1; XM_013122816.1.
DR AlphaFoldDB; A0A1U8CIF3; -.
DR STRING; 10036.ENSMAUP00000019248; -.
DR eggNOG; KOG0619; Eukaryota.
DR eggNOG; KOG2087; Eukaryota.
DR OrthoDB; 2913881at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR008112; Relaxin_rcpt.
DR PANTHER; PTHR24372; GLYCOPROTEIN HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24372:SF72; RELAXIN RECEPTOR 2; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF13855; LRR_8; 2.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01739; RELAXINR.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00365; LRR_SD22; 3.
DR SMART; SM00369; LRR_TYP; 10.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS51450; LRR; 3.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_012978270.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 464..486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 498..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 583..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 637..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 680..703
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 715..737
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 476..735
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT DISULFID 109..124
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 798 AA; 89782 MW; 0B25045F3B5085C9 CRC64;
MDQFSPSIVV LGSPGNQTVE RDFSPVTQVT TPDKVPSLPS AKTRRKILHL PHSNAVILNL
WVVTPLGVKD PFMAQDFVLA DSSMVAPLCQ KGYFPCGNLT KCLPRAFHCD GVDDCENGAD
EDNCGDTSGW ATIFGTVHGN VNKVTLTQEC FLNQYPQHCY CRENELECIK ADLKAVPKVS
SNVTLLSLKK NKIHRLPVKV FSKYTELEKI YLQHNCITHI SRKAFFGLYN LQILYLSHNC
ITALRPGTFK DLHHLTWLIL DDNPITSISQ RSFTGLNSLF FLSMVNNQLE VLPERLCAQM
PHLNWMDLAN NEIKYLTNST FLTCDSLTVL FLPRNQIGFV PEMTFSSLKN LGELDLSSNM
ITKLPAHIFS DLHLLQKLNL SSNPLLYVHK SQFGSLKQLQ SLDLERIEIP NISTGMFQPM
KNLSHIYLKT FRYCSYVPHV RICMPSTDGI SSSEDLLANS ILRVSVWVIA FITSVGNFLV
IAVRSLIKAE NTTHAMSIKI LCCADCLMGV YLFFVGVFDM KYRGQYQKYA LLWMESVPCR
LLGFLATLST EVSVLLLTFL TLEKFLVIVF PFSNLRLGKR QTAVALAAIW GLGFLIAAIP
FTSEDYFGNF YGKNGVCFPL HYDQAEDFGS RGYSLGIFLG VNLLAFLIIV FSYVAMFCSI
QKTSLQTAEV RNHIGKEVAV ANRFFFIVFS DAICWIPVFV VKILSLLQVE VPGTITSWIV
VFFLPVNSAL NPILYTLTTS FFKDKLKQLL HKHRRKSIFK VKKKSLSTSI VWTDDSSLKL
GVLNRIALGD NIMKPVSP
//
