ID A0A1U8CMS3_MESAU Unreviewed; 297 AA.
AC A0A1U8CMS3;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Tumor necrosis factor receptor superfamily member 5 {ECO:0000256|ARBA:ARBA00015766};
DE AltName: Full=B-cell surface antigen CD40 {ECO:0000256|ARBA:ARBA00031089};
DE AltName: Full=CD40L receptor {ECO:0000256|ARBA:ARBA00032719};
GN Name=Cd40 {ECO:0000313|RefSeq:XP_012979845.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012979845.1};
RN [1] {ECO:0000313|RefSeq:XP_012979845.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR RefSeq; XP_012979845.1; XM_013124391.2.
DR AlphaFoldDB; A0A1U8CMS3; -.
DR GeneID; 101822705; -.
DR CTD; 958; -.
DR OrthoDB; 4574260at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0042113; P:B cell activation; IEA:InterPro.
DR GO; GO:0050776; P:regulation of immune response; IEA:InterPro.
DR CDD; cd13407; TNFRSF5; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 4.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR020435; TNFR_5.
DR InterPro; IPR034021; TNFRSF5_N.
DR PANTHER; PTHR46875; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 5; 1.
DR PANTHER; PTHR46875:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 5; 1.
DR Pfam; PF00020; TNFR_c6; 3.
DR PRINTS; PR01922; TNFACTORR5.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00206}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_012979845.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..297
FT /note="Tumor necrosis factor receptor superfamily member 5"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010530563"
FT TRANSMEM 194..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 61..103
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 61..103
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 104..143
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 104..143
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 145..186
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 145..186
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DISULFID 62..77
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 125..143
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 146..161
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 297 AA; 32829 MW; 9FCA68EE702D844A CRC64;
MVTLPRQCVL WGCLLTAVHL GQCVTCSDKQ YLFNGQCCDL CQPGRRLESH CTALAKTQCL
LCDSGEFMSK WNKEPRCYQH THCEPKEGLE VEKEGTADTD TICACKEGQH CTSKECERCA
QHTSCGPGFG VKQMASRTAD TVCEPCPAGF FSSGPSAFEQ CRPWTSCEAQ NMVVRQEGTN
TTDAVCGLRP RMRALLVIPI VMVILTTIFI VVSFCIKKVV KEPKDNKSLP HCEEPGTIIR
ITLPVLSSGM EHREVQPLED SRWNQRGSFF CWLTLTLEVS CQISCVQQGA GGLTPCC
//
