ID A0A1U8CP44_MESAU Unreviewed; 734 AA.
AC A0A1U8CP44;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Bromodomain-containing protein 2 {ECO:0000256|ARBA:ARBA00040998};
GN Name=Brd2 {ECO:0000313|RefSeq:XP_012981291.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012981291.1};
RN [1] {ECO:0000313|RefSeq:XP_012981291.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer. Interacts with E2F1 and with histone H4 acetylated
CC at 'Lys-13'. {ECO:0000256|ARBA:ARBA00038820}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_012981291.1; XM_013125837.2.
DR AlphaFoldDB; A0A1U8CP44; -.
DR GeneID; 101835908; -.
DR CTD; 6046; -.
DR OrthoDB; 152619at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd05498; Bromo_Brdt_II_like; 1.
DR Gene3D; 1.20.1270.220; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR InterPro; IPR043509; Bromo_Brdt_II.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR027353; NET_dom.
DR InterPro; IPR038336; NET_sf.
DR PANTHER; PTHR22880:SF240; BROMODOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR22880; FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS; 1.
DR Pfam; PF17035; BET; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 2.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 2.
DR PROSITE; PS51525; NET; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 47..98
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 299..371
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 565..647
FT /note="NET"
FT /evidence="ECO:0000259|PROSITE:PS51525"
FT REGION 204..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..271
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..445
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..460
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..497
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..514
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..580
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..734
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 734 AA; 80723 MW; 28D53D7B7CC2DCC4 CRC64;
MAVPAACGRR EAGPADFPPL VGRGPRWPKF LASSFPSCSP WIATPEDYHK IIKQPMDMGT
IKRRLENNYY WAASECMQDF NTMFTNCYIY NKPTDDIVLM AQTLEKIFLQ KVASMPQEEQ
ELVVTVPKNS HKKGAKLAAL QGSIASAHQV PAVSSVSHTA LYTPPPEIPT TVLTIPHPSV
ISSPLLKSLH SAGPPLLAVS AAPPAQPLAK KKGVKRKADT TTPTPTAMLA PGSPASPPGS
LEPKAARLPP VRRESGRPIK PPRKDLPDSQ QQHQSSKKGK LSEQLKHCNG ILKELLSKKH
AAYAWPFYKP VDASALGLHD YHDIIKHPMD LSTVKRKMEN RDYRDAQEFA ADVRLMFSNC
YKYNPPDHDV VAMARKLQDV FEFRYAKMPD EPLEPGPLPV STALPPGLAK SSSESSSEES
SSESSSEEEE EEEDEDEEEE SESSDSEEER AHRLAELQEQ LRAVHEQLAA LSQGPISKPK
RKREKKEKKK KRKAEKHRGR AGMDEDDKGS RAPRPLQPKK SKKAGGGGSA AMLSHPGFGT
CGGGGNKPPK KAQKAAPPVL PAGYDSEEEE ESRPMSYDEK RQLSLDINKL PGEKLGRVVH
IIQAREPSLR DSNPEEIEID FETLKPSTLR ELERYVLSCL RKKPRKPYTI KKPVGKTKEE
LALEKKRELE KRLQDVSGQL NSTKKPPKKA SEKTETSSAQ QVAVSRLSAS SSSSDSSSSS
SSSSSSDTSD SDSG
//
