ID A0A1U8CPX7_MESAU Unreviewed; 2205 AA.
AC A0A1U8CPX7;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Dedicator of cytokinesis protein 10 isoform X3 {ECO:0000313|RefSeq:XP_012977818.1};
GN Name=Dock10 {ECO:0000313|RefSeq:XP_012977818.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012977818.1};
RN [1] {ECO:0000313|RefSeq:XP_012977818.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR RefSeq; XP_012977818.1; XM_013122364.2.
DR GeneID; 101830814; -.
DR CTD; 55619; -.
DR OrthoDB; 5480873at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11699; DHR2_DOCK10; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF71; DEDICATOR OF CYTOKINESIS PROTEIN 10; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 2.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT DOMAIN 193..302
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 684..862
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1702..2162
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 153..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1303..1323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2184..2205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2205 AA; 251833 MW; 04B7B98B2C20368D CRC64;
MGCTASIVLL QAFRSVIQRS CPHICRRRQE EPSHEIVPLE SDDEMSRPRT LIMQEKPRLL
EPLDYETVIE ELEKTHRNDP LQDLLFFPSD DFSTATVSWD IRTLYSTVPE EAEHKAESLL
VKEACKFYSS QWYVVNYKYE QYSGDIRQLP RAEHKPEKLP SHSFEVDHED ADKDEDTTSH
SSSKGGGGAG GTGVFKSGWL YKGNFNSTVN NTVTVRSFKK RYFQLTQLPD NSYIMNFYKD
EKISKEPKGC IFLDSCTGVV QNNRLRKYAF ELKMNDLTYF VLAAETESDM DEWIHTLNRI
LQISPEGALQ GRKSAELAEL GLDPLDNSVT CECTLEETDS SENSLHADFA KYLTETEETV
KTMRNIDRLN LFSLDPDIDT LKLQKRDLFE NEFVVKPFEE KAAKRIMVIC RALNFSLQGS
VTENENDPVT NIEPFFVSVA LYDLRDSRKI SADFHVDLNH PAVRQMLSGA PPALENGNID
PGTPRQSEEP HIKGLPEEWL KFPKQAIFSV SDPHSEIVLV AKVEKVLMGN IGSSAEPYIK
NPDSNKFAQK ILKSNRQFCS KLGKYRMPFA WAVRSVFKDN QGNVDRDSRF SPLYRQESSK
ISAEDLLKLV SDYRRADRIG KMQTIPGSLD IVVDNIPLEQ PNCVTSSFIP VKPFNVMAQS
EPTVEVEEFI YDSTKYCRPY RVYKNQIYVY PKHLKYDSQK CFNKARNITV CIEFKNSDED
GAKPMKCIYG KPGGPLFTSA AYTAVLHHSQ NPDFSDEVKI ELPTQLHEKH HLLFSFYHIT
CDINAKANAK KKEALETSVG YAWLPLMKHD QIASQEYNIP ITTTLPPNYL SIQDSASGKQ
GGSDIKWVDG GKPLFKVSTF VVSTVNTQDP YVNAFFHQCQ KREKDMSQSP TSSFVQACKN
LLNVDKIHSI MSFLPIILNQ LFKILVQNEE EEISATITRV LADIVAKCHE EQLDHSVQSY
IKFVFKTRSY KERTIHEELT KNLSDLLKSN DSTIVKHVLK HSWFFFAIIL KSMAQHLTDT
NKIQLPRAQR FPESYQSELD NLVMGLCDHV IWKYKDALEE TKRANHSVAR FLKRCFTFMD
RGFVFKMVNN YVSMFSSGEF KTLCQYKFDF LQEVCQHEHF IPLCLPIRSA NIPDPLTPSE
SIQELHASDM PEYSVTNEFC RKHFLIGILL REVGFALQED QDIRHLALAV LKNLMAKHSF
DDRYREPRKQ AQIASLYMPL YGMLLDNMPR IYLKDLYPFT VNTSNQGSRD DLSTNGGFQT
QTSMKHATSV DTSFSKDVLN SIAAFSSIAI STVNHADSRA SLASLDSNPS TTEKSSEKTD
NCEKIPRPLS LIGSTLRFDK LDQAETRSLL MCFLHIMKTI SVETLIAYWQ RAPSPEVSDF
FSILDVCLQN FRYLGKRNII RKIAAAFKFV QSTQNNGTLK GSNPSCQTSG LLSQWMHTTS
GHEGHKQHRS QTLPIIRGKN ALSNPKLLQM LDNTMNSNSN EIDIVHHVDT EANIATEVCL
TILDLLSLFT QVHQRQLQQS DCQNSLMKRV FDTYMLFFQV NQSATALKHV FASLRLFVCK
FPSALFQGPA DLCGSFCYEV LKCCNHRSRS TQMEAAALLY FFMRKNFEFN KQRSIVRSHL
QLIKAVSQLI ADAGIGGSRF QHSLAITNNF ANGDKQMKNS NFPAEVKDLT KRIRTVLMAT
AQMKEHEKDP EMLVDLQYSL ANSYASTPEL RRTWLESMAK IHARNGDLSE AAMCYIHIAA
LIAEYLKRKG YWKMEKICTP PLLPEDTHPC DSNPLLTTPG GGSMFSMGWP AFLSITPNIK
EEGAMKEDSG MQDTPYNESI LVEQLYMCVE FLWKSERYEL IADVNKPIIA VFEKQRDFKK
LSDLYYDIHR SYLKVAEVVN SEKRLFGRYY RVAFYGQGFF EEEEGKEYIY KEPKLTGLSE
ISQRLLKLYA DKFGADNVKI IQDSNKVNPK DLDPKYAYIQ VTYVTPFFEE KEIEDRKTDF
EMHHNINRFV FETPFTLSGK KHGGVAEQCK RRTVLTTSHL FPYVKKRIQV ISQSSTELNP
IEVAIDEMSR KVSELNQLCT TDEVDMIRLQ LKLQGSVSVK VNAGPMAYAR AFLEETNAKK
YPDNQVKLLK EIFRQFADAC GQALDVNERL IKEDQLEYQE ELRSHYKDML SELSAIMNEQ
LCRGPCLYSF CSSVSSVSLS AVSKSDYGQG RPSKARSGAT LHTYN
//
