ID A0A1U8CR43_MESAU Unreviewed; 812 AA.
AC A0A1U8CR43;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Microcephalin {ECO:0000256|ARBA:ARBA00017027};
GN Name=Mcph1 {ECO:0000313|RefSeq:XP_012977889.2};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012977889.2};
RN [1] {ECO:0000313|RefSeq:XP_012977889.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26319212;
RA Ying B., Toth K., Spencer J.F., Aurora R., Wold W.S.;
RT "Transcriptome sequencing and development of an expression microarray
RT platform for liver infection in adenovirus type 5-infected Syrian golden
RT hamsters.";
RL Virology 485:305-312(2015).
RN [2] {ECO:0000313|RefSeq:XP_012977889.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Implicated in chromosome condensation and DNA damage induced
CC cellular responses. May play a role in neurogenesis and regulation of
CC the size of the cerebral cortex. {ECO:0000256|ARBA:ARBA00025455}.
CC -!- SUBUNIT: Interacts with CDC27 and maybe other components of the APC/C
CC complex. Interacts with histone variant H2AX under DNA damage
CC conditions. {ECO:0000256|ARBA:ARBA00026061}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
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DR RefSeq; XP_012977889.2; XM_013122435.2.
DR AlphaFoldDB; A0A1U8CR43; -.
DR OrthoDB; 76720at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0021987; P:cerebral cortex development; IEA:InterPro.
DR CDD; cd17716; BRCT_microcephalin_rpt1; 1.
DR CDD; cd17736; BRCT_microcephalin_rpt2; 1.
DR CDD; cd17751; BRCT_microcephalin_rpt3; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 3.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR022047; Microcephalin-like.
DR InterPro; IPR029504; Microcephalin_mammal.
DR PANTHER; PTHR14625; MICROCEPHALIN; 1.
DR PANTHER; PTHR14625:SF3; MICROCEPHALIN; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF12258; Microcephalin; 1.
DR Pfam; PF12738; PTCB-BRCT; 1.
DR SMART; SM00292; BRCT; 3.
DR SUPFAM; SSF52113; BRCT domain; 3.
DR PROSITE; PS50172; BRCT; 3.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT DOMAIN 7..99
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 649..707
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 728..810
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 265..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..316
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..545
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 812 AA; 90021 MW; 273024B2BF05B8A2 CRC64;
METSGGAGGA FLKDIVAYVE VWSSNGTENY SKTFTKQLED MGATVSKTLN KQVTHVIFKD
GYQSTWDKAR KTGAKLVSVL WVEKCRMTGA HVDESLFPAV NTNEELPSLI RKKHKCMQPK
DFIPKTPEND KRLQKKFEKM AEELQKQKTT LDDGVPVLLF ESPRSLVYSS TTPIKSHKTT
MENRLQEMRE KRENLSPTFS QMLEQSQQNP NVSLCEASLN IAHESLRSDE SFASCPRSSF
DGLCGNQERK LGRSVNEMAR MACSSSPVLK TSSSYSSLSP NHLSQPSPQK AKDHPPEEGI
SWQKDASGEK AELEREQAAS VSQGMLCLSP ATAGNIDAID EPKSCSAKRK RPMDLGSPPK
GKLKKKRYNR KSALPIQLFK SDRSPILRTP DVGASSYEDY FSPDNLKERY SEALPPEAQP
LSSPSLFHCR SLSKWERSSI LEMCDFTFIG DKPRSISFTD SVSRSTSSLE KPGKEEVSTV
SRCIVVETSA KGSPELCRQP GPQLREDAAP QGSTLANTPS SPAHRIMPLK GDSKEERDHV
DVKGSPEDST TPPASASSEG EAHSFNFGRD CNVEKSIEEK NKSTGYSESI KNGPVKPESS
DGSCTDLVRP QEKPKKCGKE KKTVRTLVMT SMPSEKQSLI IQVVNTLKGF SFAPEVCEST
SHVLVGKSVR TLNVLMGIAR GCWILSYEWV LWSLELGHWI SEEPFELSES FPAAPVCRLE
RQLSTRRYQG TLFANQPKMF IAPASSPPRA KLCELVLLCG GQVSPSPQQA SLIIGPYCGK
KEARIQYLSE KWVLDSITQH KVCDFNNYQL LQ
//
