ID   A0A1U8CU15_ALLSI        Unreviewed;       742 AA.
AC   A0A1U8CU15;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Solute carrier family 12 member 8 isoform X1 {ECO:0000313|RefSeq:XP_014372528.1, ECO:0000313|RefSeq:XP_025052742.1};
GN   Name=SLC12A8 {ECO:0000313|RefSeq:XP_014372528.1,
GN   ECO:0000313|RefSeq:XP_025052742.1, ECO:0000313|RefSeq:XP_025052743.1,
GN   ECO:0000313|RefSeq:XP_025052744.1};
OS   Alligator sinensis (Chinese alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_014372528.1};
RN   [1] {ECO:0000313|RefSeq:XP_014372528.1, ECO:0000313|RefSeq:XP_025052742.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC       {ECO:0000256|ARBA:ARBA00010593}.
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DR   RefSeq; XP_014372528.1; XM_014517042.2.
DR   RefSeq; XP_025052742.1; XM_025196957.1.
DR   RefSeq; XP_025052743.1; XM_025196958.1.
DR   RefSeq; XP_025052744.1; XM_025196959.1.
DR   STRING; 38654.A0A1U8CU15; -.
DR   GeneID; 102373293; -.
DR   KEGG; asn:102373293; -.
DR   CTD; 84561; -.
DR   eggNOG; KOG2083; Eukaryota.
DR   OrthoDB; 5403154at2759; -.
DR   Proteomes; UP000189705; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR004842; SLC12A_fam.
DR   PANTHER; PTHR11827:SF6; SOLUTE CARRIER FAMILY 12 MEMBER 8; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        50..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        84..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        118..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        161..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        197..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        246..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        279..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        322..344
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        374..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        405..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        626..658
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          58..427
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   REGION          429..458
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          485..513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          538..571
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        437..458
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        485..504
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        544..558
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   742 AA;  82569 MW;  2D84B37CC7D19D51 CRC64;
     MKGRTFPPSD TMATRSDGHV QELFHEEAQQ VSQTQTKPWW KIQLFVWEPV LFGTWDGVFT
     SCMINIFGVV LFLRTGWLVG NTGILMGMFL VSFVVLVALV TVLSGIGVCE RCSIGSGGVY
     SMISTVLGGQ VGGTIGLLYI FGQCVAGAMY VTGFAESISD LLNLSNIWAV RGISLAVLLG
     LLGINLAGVK WIIRLQLLLL FLLAVSTLDF VIGSFTHLDP EHGFVGYSEE LMFNNTLPEY
     SPGESFFTVF GVFFPAATGV MAGFNMSGDL QKPATNIPLG SLAAIGTSWF LYMIFVFLLG
     AICTRESLRY DFMIAEKVSL VGFLFLLGLY ISSLASCMGG LYGAPRILQC IAQEKVIPIL
     AFLGHGKGPN KTPVAAICLT SLITMAFVFV GQVNVLAPIV TINFMLTYIV VDYSYFSVSM
     SYSLQQKSRR TQKETSRSAH CSQPLIFNKP SRYGSDGIVQ SRTDGTLLEF TKDMDQLFKP
     FSKDLGTRKE DEEKDKDVSQ KVKPKKIKKP AKQTLQDSFL LDLDRRVSPA HDCDAKSLEL
     SEERQQSFAK QNQPCERSPH LSPARDPKQK RGDELMEYGD ELFNEMQDPR NQKVEDSNGK
     QQNQELEIQR MPESFYSRLC NRWVSLAGAI GSLVIMFIIQ WIYTLVNLAV AIILYFYIGQ
     VNPGLPPGAA ANFSFFKWIK LLLSNLCRRR PSPEERIVVT PSFATVGMET TQLTEENADF
     ASRDRYHHSS VISRAEFVNQ FQ
//