ID A0A1U8CUM7_ALLSI Unreviewed; 248 AA.
AC A0A1U8CUM7;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=17-beta-hydroxysteroid dehydrogenase 14 isoform X2 {ECO:0000313|RefSeq:XP_014372742.1};
GN Name=HSD17B14 {ECO:0000313|RefSeq:XP_014372742.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_014372742.1};
RN [1] {ECO:0000313|RefSeq:XP_014372742.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH;
CC Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469,
CC ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62;
CC Evidence={ECO:0000256|ARBA:ARBA00036587};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24613;
CC Evidence={ECO:0000256|ARBA:ARBA00036587};
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DR RefSeq; XP_014372742.1; XM_014517256.2.
DR AlphaFoldDB; A0A1U8CUM7; -.
DR GeneID; 102377059; -.
DR CTD; 51171; -.
DR OrthoDB; 102925at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR43658:SF13; 17-BETA-HYDROXYSTEROID DEHYDROGENASE 14; 1.
DR PANTHER; PTHR43658; SHORT-CHAIN DEHYDROGENASE/REDUCTASE; 1.
DR Pfam; PF13561; adh_short_C2; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705}.
SQ SEQUENCE 248 AA; 26835 MW; 38241A1254F1BB39 CRC64;
MWSSVPQKLK LFLPTPLPFS LAEEVGEALE QALKESGGPG KPFFWPCDVT SEQDIQALVS
TTLQHFGHLD CLVNNAGQHP PEQEIDDISP QKFRELLEIN LIGYFLMAKF ALPHLRKTQG
NIINISSLVG VFGQRQAVPY VATKGAVTAM TKAMAIDESR YGVRVNSISP GNIWTPMWAE
LARQTANPKA VIQAGKEAQL LARMGTPKEC ARAVLYLAAD ATFCTGIDLL LSGGAELGYA
PKSQPAAS
//
