ID A0A1U8CUU7_ALLSI Unreviewed; 1764 AA.
AC A0A1U8CUU7;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Kinase D-interacting substrate of 220 kDa isoform X3 {ECO:0000313|RefSeq:XP_014372808.1};
GN Name=KIDINS220 {ECO:0000313|RefSeq:XP_014372808.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_014372808.1};
RN [1] {ECO:0000313|RefSeq:XP_014372808.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_014372808.1; XM_014517322.2.
DR GeneID; 102371799; -.
DR CTD; 57498; -.
DR OrthoDB; 5474354at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011646; KAP_P-loop.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR24116; KINASE D-INTERACTING SUBSTRATE OF 220 KDA; 1.
DR PANTHER; PTHR24116:SF0; KINASE D-INTERACTING SUBSTRATE OF 220 KDA; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF07693; KAP_NTPase; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 12.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 8.
DR PROSITE; PS50088; ANK_REPEAT; 9.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Kinase {ECO:0000313|RefSeq:XP_014372808.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000313|RefSeq:XP_014372808.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 498..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 525..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 661..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 693..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 37..69
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 103..135
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 137..169
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 170..202
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 203..235
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 236..268
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 269..301
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 335..367
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 368..391
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 441..953
FT /note="KAP NTPase"
FT /evidence="ECO:0000259|Pfam:PF07693"
FT REGION 1171..1190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1331..1359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1389..1490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1512..1559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1571..1628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1676..1744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1336..1359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1389..1422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1424..1447
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1448..1465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1524..1558
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1581..1595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1596..1619
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1676..1697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1705..1744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1764 AA; 195605 MW; 780229DC5871FA96 CRC64;
MASLMTQSLL TYVEEGNVPA LKALLEKCKD VDERNENGQT PLMLAAEQGN LEIVQELLKK
GANCNLEDSD NWTALISASK EGHVDIVAEL LNCNVNLEHR DMGGWTALMW ASYKGRTEVA
ELLLEKGSNP NITGLQYSVY PVIWAAGRGH SDIVRLLLQH GAKVNCSDKY GTTPLIWAAR
KGHLECVKYL LQMGADVDQE GANSMTALIV AVKGGYTDSV KEILKRNPNV NLTDKDGNTA
LMIASKEGHT EIVQDLLDAG TYVNIPDRSG DTVLIGAVRG GHVEIVRALL HKYADIDIRG
QDNKTALYWA VEKGNATMVR DILQCNPDTE ICTKDGETPL IKATKMRNIE IVELLLDKGA
KVSAIDKKGD TPLHIAIRGR SRKLAELLLR NPKDGRLLYR PNKAGETPYN IDCSHQKSIL
TQIFGARHLS PTESDGDMLG YDLYSSALAD ILSEPTMQPP ICVGLYAQWG SGKSFLLKKL
EDEMKTFAGQ QIEPLFQFSW LIVFLTLMVC GGLGLLLAFT VDTKLGIAVA LSLLAVLYIF
FAVIYFGGQR EGESWNWAWV LSTRLARHIG YLELLLKLMF VNPPELPEQT TKALPVRFLF
TDYNRLSSVG GETSLAEMIA TLSDACEREF GFLATRLFRV FKTEDTQGKK KWKKTCCLPS
FVIFLFILSC IIAGITLLAI FNIDPKNMTV NAILISVACV VGLAFILNCR TWWQVIDSVL
NSQRKRLHNA ASKLHKLKSE GFMKVLKCEV ELMAKMAKTI DSFTQNQTRL VVIIDGLDAC
EQDKVLQMLD TVRVLFSKGP FIAIFASDPH IIIKAINQNL NSVLRDSNIN GHDYMRNIVH
LPVFLNSRGL SSAKKLMVAA TTNGDVPYSD NAGFHEEVDR RVSQNSLGEM TKLGSKTALN
RRDTYRRRQM QRTITRQMSF DLTKLLVTED WFSDISPQTM RRLLNIVSVT GRLLRANQIT
FNWDRLASWI NLTEQWPYRT SWLILYLEET EGVPDQLTLK TIYERISKNI PTTKDVEPLL
EIDGDIRNFE VFLSSRTPVL IARDVKIFLP CTVNLDPKLR EIIADVRAAR DQMNIGGLPY
PTLPLHEAPA RASSVFSQPS SVCSSSTSFN GPFNGGVLSP QPHSSYYSGM TGPQHPFYNR
PFFAPYVYMP RYYPGSSHLI SRPPLKTSLS RDQNNGLGTG AITGSATGGS HASLSSMTVE
SVCEKLKQIE GLDQNMLSQY CATIKKANIN GRVLAQCNTE ELKREMNMNF GDWHLFKSMV
LEMRNSENQA IHEDSRGASE HVTNVIPHNE LARRSGHNSE LPHTELTGLS GQAPYALNFS
FEELNTIGLD EAPPRHSNLS WQSQTRRTPS LSSLNSQDSS IEISKLTDKV QAEYRDAYRE
YIAQMSQLEG GASSTTVSGR SSPHSTTAFY MGQSTSGGSL HSGIEQEKGK DGEQKQDDGR
KSFLLKRNDV DYSTSGVSTN DASPLDPITE EDEKSDQSGS KLLPGKKSSE RTSIFQAADI
KLKGVTLRYQ KLPSDEDESG TEESDNTPLL KEGKDKKMDG KMDKQPKSPE HGSEPIRTFI
KAKEYLTDAL LDKKDSSDSG VRSNESSPNH SLHNEGADDS QLEKANLIEL EDDSHSGKRG
IPHSLSGLQD PAVVRMSICS EDKKSPSESS LIASSPEENW PACQKVYNLN RTPSTVTLNN
NSAPANRGNQ NFEETEGIRE SPQIILRPGT SSNSTAVQNE NLKSVAHKRS QRSSYTRLSK
DASELHTVTA SDAAGFGEER ESIL
//
